Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus
文献类型：期刊论文
| 作者 | Yan MH1,2; Cheng P1,2; Jiang ZY1; Ma YB1; Zhang XM1; Zhang FX3; Yang LM4; Zheng YT4; Chen JJ[*]1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2008 |
| 卷号 | 71期号:5页码:760-763 |
| ISSN号 | 0163-3864 |
| 通讯作者 | chenjj@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of periglaucine A (1) was confirmed by single-crystal X-ray diffraction. Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 mu M in C8166 cells (SI = 45.7 and 18.8), respectively. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (No. 30672522) and guided project of the Chinese Academy of Sciences (No. KSCX1- YW-R-24). |
| 原文出处 | 200871760.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4637]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People’s Republic of China 2.Graduate UniVersity of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 3.Institute of Tropical Medicine Sciences, Guangzhou UniVersity of Traditional Chinese Medicines, Guangzhou 510405, People’s Republic of China 4.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yan MH,Cheng P,Jiang ZY,et al. Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(5):760-763. |
| APA | Yan MH.,Cheng P.,Jiang ZY.,Ma YB.,Zhang XM.,...&Chen JJ[*].(2008).Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.JOURNAL OF NATURAL PRODUCTS,71(5),760-763. |
| MLA | Yan MH,et al."Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus".JOURNAL OF NATURAL PRODUCTS 71.5(2008):760-763. |
入库方式： OAI收割
来源：昆明动物研究所
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