Compounds from Kadsura heteroclita and related anti-HIV activity
文献类型：期刊论文
| 作者 | Pu JX1; Yang LM2; Xiao WL1; Li RT3; Lei C1; Gao XM1; Huang SX1; Li SH1; Zheng YT2; Huang H4 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 69期号:5页码:1266-1272 |
| 关键词 | Kadsura heteroclita Schisandraceae triterpenoid dibenzocyclooctadiene type lignans Anti-HIV-1 activity |
| ISSN号 | 0031-9422 |
| 通讯作者 | hdsun@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipcdlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC(50) values of 1.6 mu g/mL, and 1.4 mu g/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra. |
| 收录类别 | SCI |
| 资助信息 | We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). |
| 原文出处 | 2008691266.pdf |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4645]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China 2.Laboratory of Molecular Immunopharmacology, key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 3.Kunming University of Science and Technology, Kunming 650204, Yunnan, PR China 4.Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China |
| 推荐引用方式 GB/T 7714 | Pu JX,Yang LM,Xiao WL,et al. Compounds from Kadsura heteroclita and related anti-HIV activity[J]. PHYTOCHEMISTRY,2008,69(5):1266-1272. |
| APA | Pu JX.,Yang LM.,Xiao WL.,Li RT.,Lei C.,...&Sun HD[*].(2008).Compounds from Kadsura heteroclita and related anti-HIV activity.PHYTOCHEMISTRY,69(5),1266-1272. |
| MLA | Pu JX,et al."Compounds from Kadsura heteroclita and related anti-HIV activity".PHYTOCHEMISTRY 69.5(2008):1266-1272. |
入库方式： OAI收割
来源：昆明动物研究所
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