Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia
文献类型：期刊论文
| 作者 | Chen JC1,3; Tian RR2; Qiu MH[*]1; Lu L1,3; Zheng YT2; Zhang ZQ1,3 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 69期号:4页码:1043-1048 |
| 关键词 | Momordica charantia Cucurbitaceae roots kuguacins A-E trinorcucurbitane triterpenoids anti-HIV-1 |
| ISSN号 | 0031-9422 |
| 通讯作者 | mhchiu@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50) > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively. |
| 收录类别 | SCI |
| 资助信息 | The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. |
| 原文出处 | 2008691043.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4649]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China |
| 推荐引用方式 GB/T 7714 | Chen JC,Tian RR,Qiu MH[*],et al. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia[J]. PHYTOCHEMISTRY,2008,69(4):1043-1048. |
| APA | Chen JC,Tian RR,Qiu MH[*],Lu L,Zheng YT,&Zhang ZQ.(2008).Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.PHYTOCHEMISTRY,69(4),1043-1048. |
| MLA | Chen JC,et al."Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia".PHYTOCHEMISTRY 69.4(2008):1043-1048. |
入库方式： OAI收割
来源：昆明动物研究所
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