中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity

文献类型:期刊论文

作者Chen JC1; Zhang GH2; Zhang ZQ1; Qiu MH[*]1; Zheng YT2; Yang LM2; Yu KB3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2008
卷号71期号:1页码:153-155
ISSN号0163-3864
通讯作者mhchiu@mail.kib.ac.cn
合作状况其它
英文摘要Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of I was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC = 0.09 mu g/mL) with a selectivity index of 16.7.
收录类别SCI
资助信息This work was supported by grants from the National Natural Science Foundation of China (Grant No. 39970086) and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support.
原文出处200871153.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/4651]  
专题昆明动物研究所_分子免疫药理学
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China
2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China
3.Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, Sichuan, People’s Republic of China
推荐引用方式
GB/T 7714
Chen JC,Zhang GH,Zhang ZQ,et al. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(1):153-155.
APA Chen JC.,Zhang GH.,Zhang ZQ.,Qiu MH[*].,Zheng YT.,...&Yu KB.(2008).Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.JOURNAL OF NATURAL PRODUCTS,71(1),153-155.
MLA Chen JC,et al."Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity".JOURNAL OF NATURAL PRODUCTS 71.1(2008):153-155.

入库方式: OAI收割

来源:昆明动物研究所

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