Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 3. Synthesis and in Vitro Anti-HIV-1 Activity of Some N-Arylsulfonylindoles
文献类型：期刊论文
| 作者 | Fan L1; Liu WQ2,3; Xu H[*]1; Yang LM2; Lv M1; Zheng YT[*]2 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2009 |
| 卷号 | 57期号:8页码:797-800 |
| 关键词 | N-arylsulfonylindole human immunodeficiency virus type 1 inhibitor |
| ISSN号 | 0009-2363 |
| 通讯作者 | orgxuhui@nwsuaf.edu.cn ; zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | In order to find compounds with superior anti human immunodeficiency virus type 1 (HIV-1) activity, twelve simple N-arylsulfonylindoles (3a-1) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Several compounds demonstrated significant anti-HIV-1 activity, especially N-(3-nitrobenzene)sulfonyl-6-methylindole (3h) and N-(3-nitrobenzene)sulfonylindole (3i) showed the highest anti-HIV-1 activity with EC50 values of 0.26 and 0.74 mu g/ml, and TI values of 543.78 and >270.27, respectively. |
| 收录类别 | SCI |
| 资助信息 | This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Educa- tion (No. 107105). We also would like to acknowledge Key Scientific and Technological projects of Yunnan province (2004NG12), National 973 proj- ect of China (2006CB504200), and the Knowledge Innovation Program of CAS (KSCX1-YW-R-24). |
| 原文出处 | 2009578797.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4663]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University; Yangling 712100, China 2.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming 650223, China 3.Graduate School of the Chinese Academy of Sciences; Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Fan L,Liu WQ,Xu H[*],et al. Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 3. Synthesis and in Vitro Anti-HIV-1 Activity of Some N-Arylsulfonylindoles[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(8):797-800. |
| APA | Fan L,Liu WQ,Xu H[*],Yang LM,Lv M,&Zheng YT[*].(2009).Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 3. Synthesis and in Vitro Anti-HIV-1 Activity of Some N-Arylsulfonylindoles.CHEMICAL & PHARMACEUTICAL BULLETIN,57(8),797-800. |
| MLA | Fan L,et al."Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 3. Synthesis and in Vitro Anti-HIV-1 Activity of Some N-Arylsulfonylindoles".CHEMICAL & PHARMACEUTICAL BULLETIN 57.8(2009):797-800. |
入库方式： OAI收割
来源：昆明动物研究所
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