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  5. 分子免疫药理学
Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

文献类型：期刊论文

作者Feng T1,2; Wang RR3; Cai XH1; Zheng YT[*]3; Luo XD[*]1
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
出版日期2010
卷号58期号:7页码:971-975
关键词Poncirus trifoliata chemical constituent prenylated flavonoid anti-human immunodeficiency virus-1 activity
ISSN号0009-2363
通讯作者zhengyt@mail.kiz.ac.cn ; xdluo@mail.kib.ac.cn
合作状况其它
中文摘要A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65.
收录类别SCI
资助信息This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses.
原文出处2010587971.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/4687]  
专题昆明动物研究所_分子免疫药理学
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Kunming 650204, P.R. China
2.Graduate School of Chinese Academy of Sciences; Beijing 100039, P .R. China
3.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming 650223, P.R. China.
推荐引用方式
GB/T 7714		 Feng T,Wang RR,Cai XH,et al. Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975.
APA Feng T,Wang RR,Cai XH,Zheng YT[*],&Luo XD[*].(2010).Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),971-975.
MLA Feng T,et al."Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):971-975.

入库方式： OAI收割

来源：昆明动物研究所

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