Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5 '-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro
文献类型：期刊论文
| 作者 | Zeng XW1; Huang N2; Xu H[*]1; Yang WB1; Yang LM2; Qu HA1; Zheng YT[*]2 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2010 |
| 卷号 | 58期号:7页码:976-979 |
| 关键词 | 8-hydroxyquinoline sulfonate acquired immune-deficiency syndrome human immunodeficiency virus-1 inhibitor |
| ISSN号 | 0009-2363 |
| 通讯作者 | orgxuhui@nwsuaf.edu.cn ; zhengyt@mail.kiz.ac.cn |
| 英文摘要 | To search for compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, ten 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates (4a-j) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Some compounds demonstrated anti-HIV-1 activity, especially 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline p-ethylbenzenesulfonate (4g) and 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline p-chlorobenzenesulfonate (41) showed the more potent anti-HIV-1 activity with 50% effective concentration (EC50) values of 2.59 and 4.01 mu g/ml, and therapeutic index (TI) values of 31.77 and 24.51, respectively. |
| 收录类别 | SCI |
| 资助信息 | This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Educa- tion (No. 107105). We also would like to acknowledge Scientific and Tech- nological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Refer- ence Reagent Program for providing cell lines and viruses. |
| 原文出处 | 2010587976.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4689]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University; Yangling 712100, China 2.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zeng XW,Huang N,Xu H[*],et al. Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5 '-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):976-979. |
| APA | Zeng XW.,Huang N.,Xu H[*].,Yang WB.,Yang LM.,...&Zheng YT[*].(2010).Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5 '-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),976-979. |
| MLA | Zeng XW,et al."Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5 '-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):976-979. |
入库方式： OAI收割
来源：昆明动物研究所
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