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  2. 昆明动物研究所
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  5. 分子免疫药理学
Chemical Constituents from the Leaves and Stems of Schisandra lancifolia

文献类型：期刊论文

作者Xiao WL1; Yang LM2; Zhang HB1,3; Xue YB1,3; Yang GY1,4; Pu JX1; Wang RR2; Zheng YT2; Sun HD[*]1
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
出版日期2010
卷号58期号:6页码:852-855
关键词nortriterpenoid lignan Schisandra lancifolia anti-human immunodeficiency virus-1 activity
ISSN号0009-2363
通讯作者hdsun@mail.kib.ac.cn
合作状况其它
英文摘要A new nortriterpenoid, 20-hydroxymicrandilactone D (1) and a novel lignan glycoside, lancilignanside A (2) were isolated from leaves and stems of Schisandra lancifolia, together with three known nortriterpenoids (3-5) and nine known phenolics (6-14). The structures of new compounds 1 and 2 were determined by detailed analysis of their 1D and 2D NMR spectra, and chemical evidences. In addition, compounds 1-2, 6-7, and 9-11 showed anti-human immunodeficiency virus (HIV)-1 activities with 50% effective concentration (EC50) in the range of 3.0-99.0 mu g/ml. Compound 12 was not bioactive in this assay with EC50 more than 200 mu g/ml.
收录类别SCI
资助信息This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences ("Xibuzhiguang" to W.-L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Program (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). We would like to acknowledge MRC AIDS Research Project (UK) and NIH AIDS Research and Reference Reagent Program (USA) for providing cell lines and virus.
原文出处2010586852.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/4697]  
专题昆明动物研究所_分子免疫药理学
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Kunming 650204, Yunnan, P.R. China
2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming 650223, Yunnan, P.R. China
3.Graduate School of the Chinese Academy of Sciences; Beijing 100039, P .R. China
4.Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science; Kunming 6501064, Yunnan, P.R. China
推荐引用方式
GB/T 7714		 Xiao WL,Yang LM,Zhang HB,et al. Chemical Constituents from the Leaves and Stems of Schisandra lancifolia[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):852-855.
APA Xiao WL.,Yang LM.,Zhang HB.,Xue YB.,Yang GY.,...&Sun HD[*].(2010).Chemical Constituents from the Leaves and Stems of Schisandra lancifolia.CHEMICAL & PHARMACEUTICAL BULLETIN,58(6),852-855.
MLA Xiao WL,et al."Chemical Constituents from the Leaves and Stems of Schisandra lancifolia".CHEMICAL & PHARMACEUTICAL BULLETIN 58.6(2010):852-855.

入库方式： OAI收割

来源：昆明动物研究所

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