Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
文献类型：期刊论文
| 作者 | Xiao WL1; Wang RR2; Zhao W1; Tian RR2; Shang SZ1; Yang LM2; Yang JH1; Pu JX1; Zheng YT2; Sun HD[*]1 |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 33期号:5页码:697-701 |
| 关键词 | Schisandra rubriflora Lignan NMR CD spectrum Anti-HIV-1 activity |
| ISSN号 | 0253-6269 |
| 通讯作者 | hdsun@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively. |
| 收录类别 | SCI |
| 资助信息 | This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). |
| 原文出处 | 2010335697.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4699]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Acad- emy of Sciences, Kunming 650204, Yunnan, China 2.Key Laboratory of Animal Models and Human Disease Mecha- nisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xiao WL,Wang RR,Zhao W,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701. |
| APA | Xiao WL.,Wang RR.,Zhao W.,Tian RR.,Shang SZ.,...&Sun HD[*].(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701. |
| MLA | Xiao WL,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701. |
入库方式： OAI收割
来源：昆明动物研究所
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