On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China
文献类型：期刊论文
| 作者 | Yang RG1; Xia XS2; Kusagawa S1; Zhang CY2; Ben KL[*]2; Takebe Y[*]1 |
| 刊名 | AIDS
 |
| 出版日期 | 2002 |
| 卷号 | 16期号:10页码:1401-1407 |
| 关键词 | China circulating recombinant forms (CRF) HIV-1 intersubtype recombinants injecting drug users molecular epidemiology unique recombinant forms (URF) Yunnan Province |
| ISSN号 | 0269-9370 |
| 通讯作者 | kben@21cn.com |
| 合作状况 | 其它 |
| 英文摘要 | Objectives: To investigate the molecular epidemiology of HIV in China's Yunnan Province, where the initial HIV-1 outbreak among injecting drug users (IDU) occurred in 1989, and to analyse the genesis and interrelationship of the epidemic with that in surrounding areas. Design: A molecular epidemiological investigation was conducted among IDU in three prefectures in Yunnan Province, including Wenshan (east), Honghe (southeast) and Dehong (west). Methods: Thirty-nine specimens were collected from consenting IDU in 2000-2001. The nucleotide sequences of 2.6 kb gag-RT and 340 base pair (bp) env (C2/V3) regions were determined. Phylogenetic tree and recombination breakpoint analyses were performed. Results: The circulating recombinant form (CRF), CRF08_BC, predominated in east Yunnan near Guangxi Province (89% in Wenshan and 81% in Honghe), whereas it was not detected in Dehong(0/14) in the west. In contrast, 71% (10/14) of the Dehong isolates were unique recombinant forms (URF), mostly between subtypes B' (Thailand variant of subtype B) and C, with distinct profiles of recombination breakpoints. The subtype B' accounts for the remaining 29% (4/14) of Dehong isolates. Interestingly, two Honghe isolates (2/16) shared some of the precise B'/C recombination breakpoints with CRF07_BC. Conclusion: New recombinant strains are arising continually in west Yunnan near the Myanmar border. Some appeared to be secondary recombinants derived from CRF07_BC that had further recombined with other strains. The uneven distribution of subtypes, CRF and URF, suggests the presence of independent transmission networks and clusters among IDU in Yunnan. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. |
| 原文出处 | 2002161401.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5237]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, The People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yang RG,Xia XS,Kusagawa S,et al. On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China[J]. AIDS,2002,16(10):1401-1407. |
| APA | Yang RG,Xia XS,Kusagawa S,Zhang CY,Ben KL[*],&Takebe Y[*].(2002).On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China.AIDS,16(10),1401-1407. |
| MLA | Yang RG,et al."On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China".AIDS 16.10(2002):1401-1407. |
入库方式： OAI收割
来源：昆明动物研究所
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