Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features
文献类型：期刊论文
| 作者 | Yu MC1,2; Cao XM1; Xu JJ1; Wang XL1; Yang J1; Wang XH3; Ben KL[*]1,2 |
| 刊名 | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 25期号:4页码:627-643 |
| 关键词 | testosterone undecanoate male contraceptive immunological parameters epithelium thickness secretory component rats |
| ISSN号 | 0892-3973 |
| 通讯作者 | kben@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Testosterone undecanoate (TU) is under phase III clinical trial as a hormonal male contraceptive in China. Sex hormones can modulate the immune system. Female hormonal contraceptives may affect SIV/HIV-1 transmission. To evaluate the safety of TU and to understand whether long-term use of TU for a male contraceptive affects users' immunological features, adult male rats were treated for a 32-week TU-treated phase at the dose of 20 mg TU/kg body weight and a 24-week recovery phase. The reproductive and immunological parameters of 4-6 rats in each subgroup were examined at the stated time point. The mean sperm count and viability in the treated rats were significantly suppressed (p < 0.01). In the TU-treated group: the mean blood leukocyte and lymphocyte counts; the proliferation indexes of T cells from peripheral blood mononuclear cells (PBMC) and spleen; and, of B cells from spleen, as well as the mean counts of blood T, NK, and B cells decreased in comparison with those of control group. These decreases were not significant (p > 0.01). Similarly, the mean serum IgM, IgG, and IgA levels and complement activity in TU-treated rats were lower than those in control group (p > 0.01), and the changes in the antibody levels of the examined genital secretions were not significant (p > 0.01). The changes in the thickness of urethra epithelium, and in secretory component (SC) expression in genitals were not observed in the treated group. These results demonstrated that long-term supraphysiological TU injection did not obviously affect the examined rat immunological parameters. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). |
| 原文出处 | 200325627.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5261]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Laboratory for Molecular and Cell Immunology, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, P.R. China 2.Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China 3.Jiangsu Institute for Family Planning, Nanjing, Jiangsu, P.R. China |
| 推荐引用方式 GB/T 7714 | Yu MC,Cao XM,Xu JJ,et al. Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features[J]. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,2003,25(4):627-643. |
| APA | Yu MC.,Cao XM.,Xu JJ.,Wang XL.,Yang J.,...&Ben KL[*].(2003).Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features.IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,25(4),627-643. |
| MLA | Yu MC,et al."Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features".IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 25.4(2003):627-643. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。