The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques
文献类型：期刊论文
| 作者 | Xia HJ1,2; Zhang GH1; Wang RR1; Zheng YT[*]1 |
| 刊名 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 6期号:6页码:433-440 |
| 关键词 | Chinese rhesus macaque leukocyte subpopulation absolute count age sex |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Non-human primates such as Chinese rhesus macaques are the favorable models for preclinical study of potential therapeutic drugs, vaccines and mechanisms of human diseases. Little is known about the normal levels of leukocyte subpopulations of Chinese rhesus macaques. To obtain these data, 100 blood samples from Chinese rhesus macaques were collected. The normal range of major leukocyte subpopulations, such as T lymphocytes, B lymphocytes, monocytes, myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs), were quantitatively analyzed by flow cytometry through BD trucount tubes. The influence of age and sex on the cell counts of leukocyte subpopulations was analyzed. The counts of CD3(+)T cells, CD3(+)CD4(+)T cells, CD3(+)CD8(+)T cells and B cells decreased with age, but those of monocytes, mDCs and pDCs had no significant correlation with age. Significant differences existed in the cell counts of most leukocyte subpopulations between the male and female groups except pDCs. Furthermore the values of the females were higher than those of the males. The study provided basic information about the leukocyte subpopulations of Chinese rhesus macaques, and it may be valuable for immunobiological study of Chinese rhesus macaques. Cellular & Molecular Immunology. 2009;6(6):433-440. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. |
| 语种 | 英语 |
| 公开日期 | 2010-11-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6424]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Xia HJ,Zhang GH,Wang RR,et al. The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(6):433-440. |
| APA | Xia HJ,Zhang GH,Wang RR,&Zheng YT[*].(2009).The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques.CELLULAR & MOLECULAR IMMUNOLOGY,6(6),433-440. |
| MLA | Xia HJ,et al."The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques".CELLULAR & MOLECULAR IMMUNOLOGY 6.6(2009):433-440. |
入库方式： OAI收割
来源：昆明动物研究所
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