Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives
文献类型：期刊论文
| 作者 | Wang B1; Ge LA2; Huang WL[*]1; Zhang HB1; Qian H1; Li J[*]3; Zheng YT4 |
| 刊名 | MEDICINAL CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 6期号:4页码:252-258 |
| 关键词 | Andrographolide anti-HIV derivatives synthesis |
| 通讯作者 | ydhuangwenlong@126.com ; lij@scut.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Recent studies indicated that andrographolide was a potential anti-HIV therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their anti-HIV activities were evaluated in vitro. As compared with TI, compounds 5c, 5d and 5i showed moderate inhibitory activities on the cytopathic effect with TI above 10. Among the derivatives, compound 5i was the best one with TI > 51 |
| 收录类别 | SCI |
| 资助信息 | The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). |
| 语种 | 英语 |
| 公开日期 | 2011-05-04 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6616]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 2.Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 3.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China 4.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Wang B,Ge LA,Huang WL[*],et al. Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives[J]. MEDICINAL CHEMISTRY,2010,6(4):252-258. |
| APA | Wang B.,Ge LA.,Huang WL[*].,Zhang HB.,Qian H.,...&Zheng YT.(2010).Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives.MEDICINAL CHEMISTRY,6(4),252-258. |
| MLA | Wang B,et al."Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives".MEDICINAL CHEMISTRY 6.4(2010):252-258. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。