Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro
文献类型：期刊论文
| 作者 | Huang N1,3; Wang Q2; Yang LM1; Xu H[*]2; Zheng YT[*]1 |
| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2011 |
| 卷号 | 8期号:7页码:602-605 |
| 关键词 | Human immunodeficiency virus-1 Inhibitor 1-Hydroxy-4-chloro-9,10-anthraquinone Acquired immunodeficiency syndrome |
| 通讯作者 | orgxuhui@nwsuaf.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | In continuation of our program aimed at the discovery and development of anti-HIV-1 agents, six 1-hydroxy-4-chloro-9, 10-anthraquinone derivatives (3-8) were prepared and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Compounds 4 and 6 exhibited the potent anti-HIV-1 activities with EC(50) values of 9.81 and 17.90 mu g/mL, and TI values of >13.58 and >11.17, respectively. It demonstrated that introduction of the alkylacyloxy or alkylsulfonyloxy group at the 1-position of 1-hydroxy-4-chloro-9,10-anthraquinone could afford the more promising and potent compound than that having arylacyloxy or arylsulfonyloxy one. |
| 收录类别 | SCI |
| 资助信息 | m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. |
| 语种 | 英语 |
| 公开日期 | 2011-09-20 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6793]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 2.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Huang N,Wang Q,Yang LM,et al. Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2011,8(7):602-605. |
| APA | Huang N,Wang Q,Yang LM,Xu H[*],&Zheng YT[*].(2011).Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro.LETTERS IN DRUG DESIGN & DISCOVERY,8(7),602-605. |
| MLA | Huang N,et al."Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro".LETTERS IN DRUG DESIGN & DISCOVERY 8.7(2011):602-605. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。