Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells
文献类型：期刊论文
| 作者 | Qin Y1; Li Y2; Liu W1; Tian RR1; Guo QQ1; Li SY2; Li HB2; Zhang DJ2; Zheng YT3; Wu L4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:11页码:e27609 |
| 其他题名 | lanke@sibs.ac.cn; Jh_wang@sibs.ac.cn |
| 通讯作者 | lanke@sibs.ac.cn ; Jh_wang@sibs.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Penicillium marneffei (P. marneffei) is considered an indicator pathogen of AIDS, and the endemicity and clinical features of P. marneffei have been described. While, how the co-infection of P. marneffei exacerbate deterioration of the immune response remains poorly understood. Here we isolated P. marneffei from the cutaneous lesions of AIDS patients and analyzed its effects on HIV-1-dendritic cells (DCs) interaction. We demonstrated that the monocyte-derived dendritic cells (MDDCs) could be activated by both thermally dimorphic forms of P. marneffei for significantly promoting HIV-1 trans-infection of CD4(+) T cells, while these activated MDDCs were refractory to HIV-1 infection. Mechanistically, P. marneffei-activated MDDCs endocytosed large amounts of HIV-1 and sequestrated the internalized viruses into tetrapasnin CD81(+) compartments potentially for proteolysis escaping. The activated MDDCs increased expression of intercellular adhesion molecule 1 and facilitated the formation of DC-T-cell conjunctions, where much more viruses were recruited. Moreover, we found that P. marneffei-stimulated MDDCs efficiently activated resting CD4+ T cells and induced more susceptible targets for viral infection. Our findings demonstrate that DC function and its interaction with HIV-1 have been modulated by opportunistic pathogens such as P. marneffei for viral dissemination and infection amplification, highlighting the importance of understanding DC-HIV-1 interaction for viral immunopathogenesis elucidation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants to Dr. Wang from the 100 Talent Program of the Chinese Academy of Sciences (KSCX2-KW-BR-1), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R210, KSCX2-EW-Q-2), the Natural Science Foundation of Shanghai (10ZR1435200), and the Natural Science Foundation of China (No. 81171567). The work was also sponsored by Shanghai Rising-Star Program (A type) (11QA1407700), the National Basic Research Program of China (973 Program) (2012CB519004) and by the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2009KIP209), and to Dr. Wang. |
| 语种 | 英语 |
| 公开日期 | 2011-12-30 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6849]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 2.The First Affiliated Hospital of Kunming Medical College, Kunming, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.Department of Veterinary Bioscience, Center for Retrovirus Research, Ohio State University, Columbus, Ohio, United States of America |
| 推荐引用方式 GB/T 7714 | Qin Y,Li Y,Liu W,et al. Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells[J]. PLOS ONE,2011,6(11):e27609. |
| APA | Qin Y.,Li Y.,Liu W.,Tian RR.,Guo QQ.,...&Wang JH[*].(2011).Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells.PLOS ONE,6(11),e27609. |
| MLA | Qin Y,et al."Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells".PLOS ONE 6.11(2011):e27609. |
入库方式： OAI收割
来源：昆明动物研究所
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