Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro
文献类型：期刊论文
| 作者 | Fan LL1; Huang N2,3; Yang RG1; He SZ1; Yang LM2; Xu H[*]1; Zheng YT[*]2 |
| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2012 |
| 卷号 | 9期号:1页码:44-47 |
| 关键词 | 5 6-Dihydro-indolo[1 2-a]quinoxaline Acquired immunodeficiency syndrome Human immunodeficiency virus-1 Inhibitor |
| 通讯作者 | orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 mu g/mL, and TI values of 63.76 and 53.60, respectively. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). |
| 语种 | 英语 |
| 公开日期 | 2012-04-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6917]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China 2.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China |
| 推荐引用方式 GB/T 7714 | Fan LL,Huang N,Yang RG,et al. Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2012,9(1):44-47. |
| APA | Fan LL.,Huang N.,Yang RG.,He SZ.,Yang LM.,...&Zheng YT[*].(2012).Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro.LETTERS IN DRUG DESIGN & DISCOVERY,9(1),44-47. |
| MLA | Fan LL,et al."Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro".LETTERS IN DRUG DESIGN & DISCOVERY 9.1(2012):44-47. |
入库方式： OAI收割
来源：昆明动物研究所
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