Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents
文献类型：期刊论文
| 作者 | Tang CL1,2; Liu YJ3,4; Wang B1,5; Gu GL1; Yang LM3; Zheng YT3; Qian H[*]1; Huang WL1 |
| 刊名 | ARCHIV DER PHARMAZIE
 |
| 出版日期 | 2012 |
| 卷号 | 345期号:8页码:647-656 |
| 关键词 | Andrographolide derivatives Anti-HIV Synthesis |
| 通讯作者 | qianhai24@163.com |
| 合作状况 | 其它 |
| 英文摘要 | In an attempt to develop potent anti-HIV drugs, 20 andrographolide derivatives were designed, synthesized, and evaluated for their in vitro anti-HIV activity. The screening results revealed that five compounds showed potent anti-HIV activities with therapeutic indices (TI) above 10. The most promising compound 6f shows a significant TI close to 34.07, with the potency to be a new lead. |
| 收录类别 | SCI |
| 资助信息 | he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). |
| 语种 | 英语 |
| WOS记录号 | WOS:000307069200008 |
| 公开日期 | 2012-09-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7023]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P . R. China 2.School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, P . R. China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P . R. China 4.Graduate School of the Chinese Academy of Sciences, Beijing, P . R. China 5.Technology Center, Jiangsu Yabang Pharmaceutical Group, Changzhou, P . R. China |
| 推荐引用方式 GB/T 7714 | Tang CL,Liu YJ,Wang B,et al. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents[J]. ARCHIV DER PHARMAZIE,2012,345(8):647-656. |
| APA | Tang CL.,Liu YJ.,Wang B.,Gu GL.,Yang LM.,...&Huang WL.(2012).Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents.ARCHIV DER PHARMAZIE,345(8),647-656. |
| MLA | Tang CL,et al."Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents".ARCHIV DER PHARMAZIE 345.8(2012):647-656. |
入库方式： OAI收割
来源：昆明动物研究所
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