Anti-angiogenesis effect of trichosanthin and the underlying mechanism
文献类型：期刊论文
| 作者 | He DX1; Jin J2; Zheng YT3; Bruce IC4; Tam S[*]5; Ma X[*]2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2013 |
| 卷号 | 430期号:2页码:735-740 |
| 关键词 | Tumor angiogenesis Trichosanthin Vascular endothelial growth factor Extracellular signal-regulated kinases |
| 通讯作者 | MTAM@cuhk.edu.hk ; maxin@jiangnan.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | The growth and metastasis of tumors depend on angiogenesis. Tumor angiogenesis is initiated by the secretion of growth factors from tumor cells; downstream signals are then triggered in pre-existing blood vessels to sprout a new vascular network. Trichosanthin (TCS) is a type I ribosome-inactivating protein that has anti-tumor activity, but the underlying mechanism remains unclear. In this study, we found that a non-toxic dose of TCS decreased the wound-healing and the migration of H5V mouse heart capillary endothelial cells (ECs) induced by human choriocarcinoma (JAR) cells, as well as the JAR-induced angiogenesis of rat third-order mesenteric arteries. TCS was effective on both tumor cells and ECs/arteries. First, TCS decreased vascular endothelial growth factor transcription and secretion by JAR cells. Second, TCS consequently inhibited the tumor cell-induced, extracellular signal-regulated kinase-mediated angiogenic signal in ECs and blood vessels. In conclusion, the ability of TCS to inhibit tumor angiogenesis contributes to its anti-tumor activity. |
| 收录类别 | SCI |
| 资助信息 | We appreciate the funding support by the School of Biomedical Sciences of the Chinese University of Hong Kong and the China National Natural Science Foundation (81100185 and 31200126) as well as Fundamental Research Funds for the Central Universities (JUSRP21134) to Dr. Xin MA and Dongxu He. |
| 语种 | 英语 |
| WOS记录号 | WOS:000314257800050 |
| 公开日期 | 2013-03-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7228]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China 2.School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.Department of Physiology, School of Medicine, Zhejiang University, Hangzhou 310058, China 5.School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China |
| 推荐引用方式 GB/T 7714 | He DX,Jin J,Zheng YT,et al. Anti-angiogenesis effect of trichosanthin and the underlying mechanism[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,430(2):735-740. |
| APA | He DX,Jin J,Zheng YT,Bruce IC,Tam S[*],&Ma X[*].(2013).Anti-angiogenesis effect of trichosanthin and the underlying mechanism.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,430(2),735-740. |
| MLA | He DX,et al."Anti-angiogenesis effect of trichosanthin and the underlying mechanism".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430.2(2013):735-740. |
入库方式： OAI收割
来源：昆明动物研究所
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