Anti-HIV activities of extracts from Pu-erh tea
文献类型：期刊论文
| 作者 | Huang N1,4; Yang LM1; Li XL2; Zheng CB3; Wang RR1; Yang YP[*]2; Zheng YT[*]1 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:5页码:347-352 |
| 关键词 | Tea Camellia sinensis Pu-erh Tea Anti-HIV agents |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | AIM: To evaluate the anti-HIV activities of extracts from two commonly forms of Pu-erh tea (fermented), green tea-like (unfermented). METHODS: The cytotoxicities of extracts on C8166, MT4 and PBMC were assessed by MTT and the anti-HIV activities of extracts were evaluated by syncytium reduction and p24 antigen assay. RESULTS: All extracts had low cyto- toxicities with the CC 50 from 120.63 to 524.95 μg·mL −1 . All extracts can inhibit HIV-induced cytopathic effects, with EC 50 various from 11.13 to 67.49 μg·mL −1 . The WEPT’s were better than EEPTs, moreover the FPT ’ s water extracts were better than the GTLPT’s especially YYP-31 with SI value 42.40. YYP-31 also inhibited HIV-1 RF and HIV-2 CBL-20 infection with EC 50 of 30.82 and 39.79 μg·mL −1 , respectively. YYP-31 reduced p24 antigen expression in HIV-1 IIIB acute infected C8166 and in HIV-1 KM018 infected PBMC with EC 50 values of 14.95 and 74.63 μg·mL −1 , respectively. YYP-31 blocked the fusion between normal C8166 cells and HIV-1 chronically infected H9 cells with EC 50 values of 234.27 μg·mL −1 . It exhibits markedly synergistic anti-HIV activity in combination with AZT but can’t inhibit activities of reverse transcriptase. CONCLUSION: Pu-erh tea extracts exhibit highly efficient anti-HIV-1 activity and can be considered to be used to as a complementary therapy or a health product to HIV patients. |
| 收录类别 | 其他 |
| 资助信息 | This project was supported by 973 Program (No. 2009CB522306), the Key Scientific and Technological Program of China (Nos. 2009ZX09501-029, 2012ZX10001-006 and 2012ZX- 10001-007), and Yunnan Province Science and Technology Project (Nos. 2007BC006, 2010GA001), NSFC (No. 81001462, 81102483) and the CAS Knowledge Innovation Project (No. KSCX1-YW-10). |
| 语种 | 英语 |
| WOS记录号 | WOS:000309035800005 |
| 公开日期 | 2013-04-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7296]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 3.School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Huang N,Yang LM,Li XL,et al. Anti-HIV activities of extracts from Pu-erh tea[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(5):347-352. |
| APA | Huang N.,Yang LM.,Li XL.,Zheng CB.,Wang RR.,...&Zheng YT[*].(2012).Anti-HIV activities of extracts from Pu-erh tea.CHINESE JOURNAL OF NATURAL MEDICINES,10(5),347-352. |
| MLA | Huang N,et al."Anti-HIV activities of extracts from Pu-erh tea".CHINESE JOURNAL OF NATURAL MEDICINES 10.5(2012):347-352. |
入库方式： OAI收割
来源：昆明动物研究所
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