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Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia
文献类型：期刊论文
| 作者 | Pang W1; Zhang CY2; Duo L3; Zhou YH1; Yao ZH1; Liu FL1; Li H4; Tu YQ5; Zheng YT[*]1 |
| 刊名 | AIDS
 |
| 出版日期 | 2012 |
| 卷号 | 26期号:9页码:1121-1129 |
| 关键词 | HIV-1 IDUs northern Myanmar recombination |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | Methods: A total of 83 HIV-1-positive serums were collected from consenting IDUs during June to August 2009. HIV-1 p17, pol, vif-env, C2V3 fragments were amplified and sequenced. Phylogenetic and bootscanning analyses were performed. Results: A very high proportion (86.1%) of HIV-1 intersubtype recombinants and very low proportion of subtypes B' (3.8%), C (7.6%) and CRF01_AE (1.3%) were found in this HIV-infected IDUs cohort. These recombinants cover all four kinds of recombination forms formed among CRF01_AE, B and C. The B/C and CRF01_AE/B/C recombinants are the two most dominant recombinants, accounting for 54.4 and 42.6% of all cases, respectively, and indicating the ongoing generation of extensive and complex HIV-1 recombination among CRF01_AE, B' and C in northern Myanmar. Intriguingly, most recombinants have different chimeric patterns from each other, forming 64 unique recombination forms (URFs) that are quite distinct from any previously identified circulating recombinant forms (CRFs) and URFs in Asia. Conclusion: The extremely high proportion of intersubtype recombinants, especially CRF01_AE/B'/C recombinants (42.6%), strongly suggests that northern Myanmar is a big forge for HIV-1 recombination among CRF01_AE, B' and C. (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from the Key Scientific and Technological Program of China (2009ZX09501–029; 2009ZX10004-902, 2012ZX10001-006, 2012ZX10001-007), National Basic Research Program of China (2009CB522306, 2012CBA01305), the NSFC (U0832601, 81071345, 81172876), the Chinese Academy of Sciences (KSCX1- YW-10, KSCX2-EW-R-13), the Scientific and Tech- nological Program of Yunnan province (2009CD109; 2010GA001). |
| 语种 | 英语 |
| WOS记录号 | WOS:000304364900008 |
| 公开日期 | 2013-04-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7337]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 2.Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 3.The Second People’s Hospital 4.Yunnan Center for Disease Control and Prevention 5.Yunnan Kunming Blood Center, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Pang W,Zhang CY,Duo L,et al. Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia[J]. AIDS,2012,26(9):1121-1129. |
| APA | Pang W.,Zhang CY.,Duo L.,Zhou YH.,Yao ZH.,...&Zheng YT[*].(2012).Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia.AIDS,26(9),1121-1129. |
| MLA | Pang W,et al."Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia".AIDS 26.9(2012):1121-1129. |
入库方式： OAI收割
来源：昆明动物研究所
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