Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(N-Arylsulfonylindol-3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV-1 Agents
文献类型：期刊论文
| 作者 | Che ZP1; Huang N2; Yu X1; Yang LM2; Ran JQ1; Zhi XY1; Xu H[*]1; Zheng YT[*]2 |
| 刊名 | COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
 |
| 出版日期 | 2013 |
| 卷号 | 16期号:5页码:400-407 |
| 关键词 | microwave heating 4-Oxadiazoline human immunodeficiency virus-1 inhibitor |
| 通讯作者 | orgxuhui@nwsuaf.edu.cn ; zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A library of new 2-alkyl-2-(N-arylsulfonylindol-3-yl)-3-N-acyl-5-aryl-1,3,4-oxadiazolines was efficiently synthesized from hydrazones and anhydrides under microwave irradiation and solvent-free conditions. Compared with the traditional procedure (100 equiv. of anhydride and 1.5-4 h of reaction time), the present methodology has the advantages of short reaction time (10-20 min), and avoiding excess of anhydride (only 1.5 equiv.). Moreover, two compounds exhibited the promising anti-HIV-1 activity when evaluated for their inhibitory activity against HIV-1 replication in acutely infected C8166 cells. |
| 收录类别 | SCI |
| 资助信息 | This work was financially in part supported by National Natural Science Foundation of China (No. 31071737), the Fok Ying Tong Education Foundation for Young Talents (No. 121032), the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045), 863 Program (2006AA020602), and 973 Program (2009CB522306). |
| 语种 | 英语 |
| WOS记录号 | WOS:000317059100005 |
| 公开日期 | 2013-05-09 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7420]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China 2.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Che ZP,Huang N,Yu X,et al. Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(N-Arylsulfonylindol-3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV-1 Agents[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2013,16(5):400-407. |
| APA | Che ZP.,Huang N.,Yu X.,Yang LM.,Ran JQ.,...&Zheng YT[*].(2013).Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(N-Arylsulfonylindol-3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV-1 Agents.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,16(5),400-407. |
| MLA | Che ZP,et al."Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(N-Arylsulfonylindol-3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV-1 Agents".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 16.5(2013):400-407. |
入库方式： OAI收割
来源：昆明动物研究所
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