Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
文献类型：期刊论文
| 作者 | Gu GL1; Lin HY[*]2; Liu YJ3,4; Yang LM3; Zheng YT3; Wang B1,5; Tang CL1,6; Qian H1; Huang WL[*]1 |
| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2013 |
| 卷号 | 10期号:2页码:155-163 |
| 关键词 | Andrographolide Derivatives Anti-HIV C8166 cells Natural products Synthesis |
| 通讯作者 | qlhy24@163.com ; ydhuangwenlong@126.com |
| 合作状况 | 其它 |
| 英文摘要 | A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09501-029), the National Natural Science Foundation of China (No. 30772647 and No. 81001363) and the National Basic Research Program of China (2009CB522306). |
| 语种 | 英语 |
| WOS记录号 | WOS:000317925100007 |
| 公开日期 | 2013-05-31 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7444]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China 2.Department of Biochemistry and Molecular Biology, Nanjing Medical University,140 Hanzhong Road, Nanjing 210029, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 5.Technology Center, Jiangsu Yabang Pharmaceutical Group, Changzhou 213163, China 6.School of Medicine and Pharmaceutics, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China |
| 推荐引用方式 GB/T 7714 | Gu GL,Lin HY[*],Liu YJ,et al. Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(2):155-163. |
| APA | Gu GL.,Lin HY[*].,Liu YJ.,Yang LM.,Zheng YT.,...&Huang WL[*].(2013).Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives.LETTERS IN DRUG DESIGN & DISCOVERY,10(2),155-163. |
| MLA | Gu GL,et al."Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives".LETTERS IN DRUG DESIGN & DISCOVERY 10.2(2013):155-163. |
入库方式： OAI收割
来源：昆明动物研究所
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