Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques
文献类型：期刊论文
| 作者 | Ma JP1,2; Xia HJ1,2; Zhang GH1; Han JB1; Zhang LG3; Zheng YT[*]1 |
| 刊名 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 9期号:5页码:410-416 |
| 关键词 | Chinese rhesus macaque chloroquine immune activation pDC SIV |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4(+) T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remains unclear. Experimental data suggest that the activation of plasmacytoid dendritic cells (pDCs) by plasma viremia may play a critical role in HIV-induced immune activation. In this study, we found that the level of immune activation was higher in the late phase of SIVmac239 infection compared with chronic infection, which suggests that immune activation might be related to disease progression in SIVmac239-infected non-human primate models. Our work also showed that chloroquine could effectively inhibit the activation of pDCs in vitro and in vivo. However, chloroquine treatment of SIVmac239-infected macaques had no significant influence on the Cellular composition of peripheral blood in these animals. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from the National Basic Research Program of China (2009CB522306 and 2012CBA01305), the National Natural Science Foundation of China (30872317, 30800113, U0832601 and 81172876), the Knowledge Innovation Program of CAS (KSCX1-YW-10 and KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2009ZX09501-029, 2012ZX10001-006 and 2012ZX10001-007) and Yunnan province (2010GA001) and the ‘Western Light’ Projects of the CAS. |
| 语种 | 英语 |
| 公开日期 | 2013-09-22 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7653]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&YunnanProvince, KunmingInstitute of Zoology,ChineseAcademyof Sciences,Kunming,China 2.Graduate University of the Chinese Academy of Sciences,Beijing,China 3.CAS Key Laboratory of Infectionand Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Ma JP,Xia HJ,Zhang GH,et al. Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2012,9(5):410-416. |
| APA | Ma JP,Xia HJ,Zhang GH,Han JB,Zhang LG,&Zheng YT[*].(2012).Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques.CELLULAR & MOLECULAR IMMUNOLOGY,9(5),410-416. |
| MLA | Ma JP,et al."Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques".CELLULAR & MOLECULAR IMMUNOLOGY 9.5(2012):410-416. |
入库方式： OAI收割
来源：昆明动物研究所
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