Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission
文献类型：期刊论文
| 作者 | Zhou YH1,4,5; Liang YB2; Pang W1; Qin WH2; Yao ZH1,4; Chen X1,4; Zhang CY[*]3; Zheng YT[*]1 |
| 刊名 | BMC INFECTIOUS DISEASES
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:X页码:e463 |
| 关键词 | LDTDs HIV-1 subtype Recombination Transmission China-Myanmar border |
| 通讯作者 | zhangcy1999@ips.ac.cn ; zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: The China-Myanmar border is a particularly interesting region that has very high prevalence of and considerable diversity of HIV-1 recombinants. Due to the transient nature of their work, long-distance truck drivers (LDTDs) have a comparatively high potential to become infected with HIV-1 and further spread virus to other individuals in the area they travel within. In this study, we hypothesized that Burmese LDTDs crossing the China-Myanmar border frequently may potentially be involved in the cross-border transmission of HIV, and contribute to the extremely high prevalence of HIV-1 inter-subtype recombinants in this border region. Methods: A molecular epidemiology study was conducted among 105 Burmese LDTDs between 2008 and 2010. HIV-1 genetic fragments including p17, pol, vif-vpr, vpr-env, and C2V3 were amplified and sequenced. The subtype characterization and HIV-1 transmission were determined by both phylogenetic and phylogeographic analyses. Results: Diverse forms of HIV-1, including subtypes CRF01_AE (41.9%), C (8.6%), B (4.8%), CRF02_AG (1.0%), and inter-subtype recombinants (33.3%), as well as dual infection (10.5%), were detected among the tested LDTDs. Phylogeographic analyses based on pure subtype revealed that 77.8% Burmese LDTDs acquired HIV-1 infection in Yunnan, and the others in Myanmar. Both the C-related and CRF01_AE-related recombinants from these LDTDs appeared to have close genetic relationship with those from IDUs in Myanmar and Dehong. Conclusions: Burmese LDTDs may contribute to HIV-1 transmission along the China-Myanmar border. The results may provide some new perspective for understanding the on-going generation and prevalence of HIV-1 recombinants in the border region. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from the NSFC (81271892, U1302224, U1202228, 81172876), Key Scientific and Technological Program of China (2012ZX10001-006, 2012ZX10001-007), National Basic Research Program of China (2012CBA01305), the Chinese Academy of Sciences (KSCX2-EW-R-13). |
| 语种 | 英语 |
| WOS记录号 | WOS:000340924400001 |
| 公开日期 | 2014-09-26 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8009]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Yunnan International Travel Healthcare Center, Kunming, Yunnan 650200, China 3.Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025, China 4.University of the Chinese Academy of Sciences, Beijing 100049, China 5.Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, College of Life Sciences, Yan’an University, Yan’an, Shaanxi 716000, China. |
| 推荐引用方式 GB/T 7714 | Zhou YH,Liang YB,Pang W,et al. Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission[J]. BMC INFECTIOUS DISEASES,2014,14(X):e463. |
| APA | Zhou YH.,Liang YB.,Pang W.,Qin WH.,Yao ZH.,...&Zheng YT[*].(2014).Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission.BMC INFECTIOUS DISEASES,14(X),e463. |
| MLA | Zhou YH,et al."Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission".BMC INFECTIOUS DISEASES 14.X(2014):e463. |
入库方式： OAI收割
来源：昆明动物研究所
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