Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta
文献类型：期刊论文
| 作者 | Gao XM1,2; Niu DY1; Meng CY1; Yao FQ1; Zhou B1; Wang RR3; Yang LM3; Zheng YT3; Hu QF[*]1; Sun HD2 |
| 刊名 | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:12页码:2021-+ |
| 关键词 | dibenzocyclooctadiene lignans anti-HIV-1 activities cytotoxicities Schisandra neglecta |
| 通讯作者 | huqiufena@aliyun.com, xwl@mail.kib.ac.cn |
| 英文摘要 | Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines. |
| 收录类别 | SCI |
| 资助信息 | This project was supported financially by the NSFYP (2012FB178), the Excellent Scientific and Technological Team of Yunnan High School (2010CI08), the Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008), and Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities) (2010XY08). |
| 语种 | 英语 |
| WOS记录号 | WOS:000328703200017 |
| 公开日期 | 2014-10-16 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8071]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming 650031, P. R. China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P. R. China |
| 推荐引用方式 GB/T 7714 | Gao XM,Niu DY,Meng CY,et al. Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2013,24(12):2021-+. |
| APA | Gao XM.,Niu DY.,Meng CY.,Yao FQ.,Zhou B.,...&Xiao WL[*].(2013).Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,24(12),2021-+. |
| MLA | Gao XM,et al."Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 24.12(2013):2021-+. |
入库方式： OAI收割
来源：昆明动物研究所
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