New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
文献类型：期刊论文
| 作者 | Gao XM1; Li YQ1; Shu LD1; Shen YQ1; Yang LY1; Yang LM3; Zheng YT3; Sun HD2; Xiao WL[*]2; Hu QF[1]*1 |
| 刊名 | BULLETIN OF THE KOREAN CHEMICAL SOCIETY
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:3页码:827-830 |
| 关键词 | Schisandra wilsoniana Nortriterpenoid Anti-HIV-1 activity Cytotoxicity |
| 通讯作者 | xwl@mail.kib.ac.cn ; huqiufena@yahoo.com |
| 合作状况 | 其它 |
| 英文摘要 | Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively. |
| 收录类别 | SCI |
| 资助信息 | This project was supported financial- ly by the Excellent Scientific and Technological Team of Yunnan High School (2010CI08), the Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008), and Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nation- alities) (2010XY08). |
| 语种 | 英语 |
| WOS记录号 | WOS:000317168200026 |
| 公开日期 | 2014-10-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8091]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P. R. China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China 3.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, P. R. China |
| 推荐引用方式 GB/T 7714 | Gao XM,Li YQ,Shu LD,et al. New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2013,34(3):827-830. |
| APA | Gao XM.,Li YQ.,Shu LD.,Shen YQ.,Yang LY.,...&Hu QF[1]*.(2013).New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,34(3),827-830. |
| MLA | Gao XM,et al."New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34.3(2013):827-830. |
入库方式： OAI收割
来源：昆明动物研究所
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