Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar.
文献类型：期刊论文
| 作者 | Zhou YH1,2; Chen X1,3; Liang YB4; Pang W1; Qin WH4; Zhang CY5; Zheng YT[*]1 |
| 刊名 | AIDS RESEARCH AND HUMAN RETROVIRUSES
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:8页码:845-850 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | The Myanmar-China border appears to be the "hot spot" region for the occurrence of HIV-1 recombination. The majority of the previous analyses of HIV-1 recombination were based on partial genomic sequences, which obviously cannot reflect the reality of the genetic diversity of HIV-1 in this area well. Here, we present a near full-length characterization of a novel HIV-1 CRF01_AE/B/C recombinant isolated from a long-distance truck driver in Northern Myanmar. It is the first description of a near full-length genomic sequence in Myanmar since 2003, and might be one of the most complicated HIV-1 chimeras ever detected in Myanmar, containing four CRF01_AE, six B segments, and five C segments separated by 14 breakpoints throughout its genome. The discovery and characterization of this new CRF01_AE/B/C recombinant indicate that intersubtype recombination is ongoing in Myanmar, continuously generating new forms of HIV-1. More work based on near full-length sequence analyses is urgently needed to better understand the genetic diversity of HIV-1 in these regions. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from the NSFC (81271892, U1302224, U1202228, and 1172876) and the Key Scientific and Technological Program of China (2012ZX10001-006 and 2012ZX10001-007). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9366]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China 2.Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University , Yan'an, Shaanxi, China 3.University of the Chinese Academy of Sciences , Beijing, China 4.Yunnan International Travel Healthcare Center , Kunming, Yunnan, China 5.Pathogen Diagnostic Center, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Zhou YH,Chen X,Liang YB,et al. Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar.[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES,2015,31(8):845-850. |
| APA | Zhou YH.,Chen X.,Liang YB.,Pang W.,Qin WH.,...&Zheng YT[*].(2015).Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar..AIDS RESEARCH AND HUMAN RETROVIRUSES,31(8),845-850. |
| MLA | Zhou YH,et al."Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar.".AIDS RESEARCH AND HUMAN RETROVIRUSES 31.8(2015):845-850. |
入库方式： OAI收割
来源：昆明动物研究所
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