Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina
文献类型：期刊论文
| 作者 | Hu QX1,2; Fan Y1,2; Xu L1,2; Pang W1; Wang SQ[1]1; Zheng YT1,2,3; Lv LB3; Yao YG[*]1,2,3 |
| 刊名 | GENE
 |
| 出版日期 | 2015 |
| 卷号 | 517期号:2页码:279-285 |
| 关键词 | Gene conversion NUMT Phylogeny Pig-tailed monkey Tandem repeat mtDNA |
| 通讯作者 | yaoyg@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | As a non-human primate, the pig-tailed macaque has received wide attention because it can be infected by HIV-1. In this study, we determined the complete mtDNA sequence of the northern pig-tailed macaque (Macaca leonina). Unexpectedly, during the amplification of the mtDNA control region (D-loop region) we observed several D-loop-like sequences, which were NUMTs (nuclear mitochondrial sequences) and a total of 14 D-loop-like NUMT haplotypes were later identified in five individuals. The neighbor-joining tree and estimated divergence time based on these D-loop-like NUMT sequences of M. leonina provide some insights into the understanding of the evolutionary history of NUMTs. D-loop-like haplotypes G and H, which also exist in the nuclear genome of mulatta, appear to have been translocated into the nuclear genome before the divergence of M. mulatta and M. leonina. The other D-loop-like NUMT haplotypes were translocated into the nuclear genome of M. leonina after the divergence of the two species. Later sequence conversion was predicted to occur among these 14 D-loop-like NUMT haplotypes. The overall structure of the mtDNA of M. leonina was found to be similar to that seen in other mammalian mitochondrial genomes. Phylogenetic analysis based on the maximum likelihood method shows M. leonina clustered with Macaca silenus among the analyzed mammalian species. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the 135 strategic project of Kunming Institute of Zoology, Chinese Academy of Sciences. Y.-T. Z. was sup- ported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-R-13). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9375]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子免疫药理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Hu QX,Fan Y,Xu L,et al. Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina[J]. GENE,2015,517(2):279-285. |
| APA | Hu QX.,Fan Y.,Xu L.,Pang W.,Wang SQ[1].,...&Yao YG[*].(2015).Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina.GENE,517(2),279-285. |
| MLA | Hu QX,et al."Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina".GENE 517.2(2015):279-285. |
入库方式： OAI收割
来源：昆明动物研究所
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