Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients
文献类型：期刊论文
| 作者 | Zhu JW1,2; Liu FL1; Mu D1,2; Deng DY3; Zheng YT[*]1,2 |
| 刊名 | JOURNAL OF MEDICAL VIROLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 88期号:6页码:987-995 |
| 关键词 | HCV HIV co-infection restriction factors type I interferon |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Host restriction factors and type I interferon are important in limiting HIV and HCV infections, yet the role of HIV, HCV mono- and co-infection in regulating these antiviral genes expression is not clear. In this study, we measured the levels of TRIM5, TRIM22, APOBEC3G, and IFN-, - mRNA expression in peripheral blood mononuclear cells of 43 HIV mono-infected, 70 HCV mono-infected and 64 HIV/HCV co-infected patients along with 98 healthy controls. We also quantified HIV and HCV viral loads in mono- and co-infected patients. The results showed that HCV, HIV mono- and co-infection differentially increased TRIM22, APOBEC3G, and IFN-, - mRNA expression while the mRNA expression of TRIM was upregulated only by HCV-mono infection. HIV/HCV co-infection was associated with higher viral load, compared to either HIV or HCV mono-infection. Additionally, we showed TRIM and TRIM22 positively correlated with IFN-, -, which could be dysregulated by HIV, HCV mono- and co-infection. Furthermore, we found TRIM22 negatively correlated with HCV viral load in mono-infected patients and APOBEC3G positively correlated with HCV viral load in co-infected patients. Collectively, our findings suggest the potential role of restriction factors in restricting HIV, HCV mono- and co-infection in vivo, which appears to be a therapeutic target for potential drug discovery. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China; Grant numbers: 30671960; U0832601; 81202366; Grant sponsor: Knowledge Innovation Program of the Chinese Academy of Sciences; Grant number: KJZD-EW-L10-02; Grant sponsor: Yunnan Applicative and Basic Research Program; Grant number: 2013FB073 |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9468]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China. 3.Department of Clinical Laboratory, the Second People's Hospital of Yunnan Province, Kunming, Yunnan, 650021, China. |
| 推荐引用方式 GB/T 7714 | Zhu JW,Liu FL,Mu D,et al. Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients[J]. JOURNAL OF MEDICAL VIROLOGY,2015,88(6):987-995. |
| APA | Zhu JW,Liu FL,Mu D,Deng DY,&Zheng YT[*].(2015).Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients.JOURNAL OF MEDICAL VIROLOGY,88(6),987-995. |
| MLA | Zhu JW,et al."Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients".JOURNAL OF MEDICAL VIROLOGY 88.6(2015):987-995. |
入库方式： OAI收割
来源：昆明动物研究所
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