Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque
文献类型：期刊论文
| 作者 | Zhang GH1; Wu RD1,2; Zheng HY1,3; Zhang XM1; Zhang MX1,4; Tian RR1,4; Liu GM2; Pang W[*]1; Zheng YT[*]1 |
| 刊名 | JOURNAL OF IMMUNOLOGY RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 2015期号:X页码:e202738 |
| 通讯作者 | pangw@mail.kiz.ac.cn ; zhengyt@mail.kiz.ac.cn |
| 英文摘要 | Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by which LPS affects disruption of immune response is still not fully understood. Chronically SHIVB'WHU-infected Chinese rhesus macaques received 50 μg/kg body weight LPS in this study. LPS administration affected the virus/host equilibrium by elevating the levels of viral replication and activating T lymphocytes. LPS induced upregulation of CD8(+) naïve T cells and downregulated the number of CD4(+) and CD8(+) T effector memory cells. The downregulated effector memory cells are associated with a lower frequency of monofunctional and polyfunctional cells, and an upregulated programmed cell death-1 (PD-1) expression on CD4(+) and CD8(+) T cells was observed in monkeys after LPS stimulation. Our data provide new insights into the function of LPS in the immune activation in SHIV/HIV infection. |
| 资助信息 | This research was supported in part by grants from the National Natural Science Foundation of China (81273251, 81172876, and 81471620), Key Scientific and Technological Program of China (2013ZX10001-002, 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), the Knowledge Innovation Pro- gram of CAS (KJZD-EW-L10-02), and the “Western Light” Projects. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9514]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China 3.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, Chin 4.University of Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Zhang GH,Wu RD,Zheng HY,et al. Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015,2015(X):e202738. |
| APA | Zhang GH.,Wu RD.,Zheng HY.,Zhang XM.,Zhang MX.,...&Zheng YT[*].(2015).Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.JOURNAL OF IMMUNOLOGY RESEARCH,2015(X),e202738. |
| MLA | Zhang GH,et al."Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque".JOURNAL OF IMMUNOLOGY RESEARCH 2015.X(2015):e202738. |
入库方式： OAI收割
来源：昆明动物研究所
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