Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239
文献类型：期刊论文
| 作者 | Zhang LT1,2; Tian RR1,3; Xia HJ1; Xia XS2; Pang W[*]1; Zheng YT[*]1; Zheng HY1,4; Pan GQ5; Tuo XY5 |
| 刊名 | IMMUNOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 147期号:4页码:443-452 |
| 关键词 | Mucosa lamina propria microbial translocation |
| 通讯作者 | pangw@mail.kiz.ac.cn ; zhengyt@mail.kiz.ac.cn |
| 英文摘要 | HIV/SIV infection can cause severe depletion of CD4+ T cells both in plasma and mucosa; it also results in damage to the gut mucosa barrier, which makes the condition more conducive to microbial translocation. In this study, we used simian immunodeficiency virus (SIV)-infected Chinese rhesus macaques to quantify the extent of microbial translocation and the function of immune cells in the entire gastrointestinal tract and to compare their differences between rapid and slow progressors. The results showed that in the slow progressors, microbial products translocated considerably and deeply into the lamina propria of gut; the tissue macrophages had no significant differences compared with the rapid progressors, but there was a slightly higher percentage of mucosal CD8+ T cells and a large amount of extracellular microbial products in the lamina propria of the intestinal mucosa of the slow progressors. The data suggested that although microbial translocation increased markedly, the mucosal macrophages and CD8+T cells were insufficient to clear the infiltrated microbes in the slow progressors. Also, therapies aimed at suppressing the translocation of microbial products in the mucosa could help delay the progression of SIV disease. |
| 资助信息 | This work was supported in part by grants from the National Basic Research Programme of China (2012CBA01305), the National Natural Science Founda- tion of China (81172876, 81471620, 81273251, U1202228, 81571606), the Key Scientific and Technological Pro- gramme of China (2012ZX10001-007, 2013ZX10001-002, 2014ZX10005-002-006), Natural Science Foundation of Yunnan Province (2014FB181) and the Knowledge Inno- vation Programme of the Chinese Academy of Sciences (KJZD-EW-L10-02). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9518]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 2.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China 4.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China 5.The Pathology Department, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China |
| 推荐引用方式 GB/T 7714 | Zhang LT,Tian RR,Xia HJ,et al. Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239[J]. IMMUNOLOGY,2016,147(4):443-452. |
| APA | Zhang LT.,Tian RR.,Xia HJ.,Xia XS.,Pang W[*].,...&Tuo XY.(2016).Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239.IMMUNOLOGY,147(4),443-452. |
| MLA | Zhang LT,et al."Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239".IMMUNOLOGY 147.4(2016):443-452. |
入库方式： OAI收割
来源：昆明动物研究所
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