Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina)
文献类型：期刊论文
| 作者 | Lian XD1,2; Zhang XH1,2; Dai ZX1; Zheng YT[*]1 |
| 刊名 | IMMUNOGENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 68期号:4页码:261-274 |
| 关键词 | AIDS model MHC class I Macaca leonina Northern pig-tailed macaque |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The northern pig-tailed macaque (Macaca leonina) has been confirmed to be an independent species from the pig-tailed macaque group of Old World monkey. We have previously reported that the northern pig-tailed macaques were also susceptible to HIV-1. Here, to make this animal a potential HIV/AIDS model and to discover the mechanism of virus control, we attempted to assess the role of major histocompatibility complex (MHC) class I-restricted immune responses to HIV-1 infection, which was associated with viral replication and disease progression. As an initial step, we first cloned and characterized the classical MHC class I gene of northern pig-tailed macaques. In this study, we identified 39 MHC class I alleles including 17 MHC-A and 22 MHC-B alleles. Out of these identified alleles, 30 were novel and 9 were identical to alleles previously reported from other macaque species. The MHC-A and MHC-B loci were both duplicates as rhesus macaques and southern pig-tailed macaques. In addition, we also detected the patterns of positive selection in northern pig-tailed macaques and revealed the existence of balance selection with 20 positive selection sites in the peptide binding region. The analysis of B and F peptide binding pockets in northern and southern pig-tailed macaques and rhesus macaques suggested that they were likely to share a few common peptides to present. Thus, this study provides important MHC immunogenetics information and adds values to northern pig-tailed macaques as a promising HIV/AIDS model. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81172876, 81373124, 81471620, 81571606), the Knowledge In- novation Program of CAS (KSCX2-EW-R-13, KJZD-EW-L10-02), the Natural Science Foundation of Yunnan Province (2014FB181), and the Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9532]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lian XD,Zhang XH,Dai ZX,et al. Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina)[J]. IMMUNOGENETICS,2016,68(4):261-274. |
| APA | Lian XD,Zhang XH,Dai ZX,&Zheng YT[*].(2016).Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina).IMMUNOGENETICS,68(4),261-274. |
| MLA | Lian XD,et al."Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina)".IMMUNOGENETICS 68.4(2016):261-274. |
入库方式： OAI收割
来源：昆明动物研究所
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