Activation of c-Jun N-terminal Kinases by Ribotoxic Stresses
文献类型：期刊论文
| 作者 | Ouyang DY1,2; Wang YY1,2; Zheng YT[*]1 |
| 刊名 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2005 |
| 卷号 | 2期号:6页码:419-425 |
| 关键词 | ribotoxic stress response JNK, MAPK apoptosis ribotoxin ribosome inactivating protein HIV |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | The c-Jun N-terminal kinases (JNKs) are classic stress-activated protein kinases. Many cellular stresses have been shown to stimulate JNK activation. In this review, we focus on ribotoxic stresses based on their multiple biological potencies including anti-HIV-1 activity. Some of the functions of ribotoxins and the signaling transduction pathway that mediated are mentioned. Different from other stimulators, ribotoxic stresses act on special motifs of 28S rRNA in translationally active mammal ribosomes. Binding and damaging on the motif leads to JNK activation and subsequently biological response to the signal initiator, which is named ribotoxic stress response. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by the Natural Science Foundation of China (30471605), the Natural Science Foundation of Yunnan Procince (2003C0001R), Key Scientific and Techno- logical Projects of China (2004BA719A14) and Yunnan Province (2004NG12), and CAS Knowledge Innovation Projects (KSCX2- SW-216; KSCX1-SW-11). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9649]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Diseases Mechanisms, and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Ouyang DY,Wang YY,Zheng YT[*]. Activation of c-Jun N-terminal Kinases by Ribotoxic Stresses[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2005,2(6):419-425. |
| APA | Ouyang DY,Wang YY,&Zheng YT[*].(2005).Activation of c-Jun N-terminal Kinases by Ribotoxic Stresses.CELLULAR & MOLECULAR IMMUNOLOGY,2(6),419-425. |
| MLA | Ouyang DY,et al."Activation of c-Jun N-terminal Kinases by Ribotoxic Stresses".CELLULAR & MOLECULAR IMMUNOLOGY 2.6(2005):419-425. |
入库方式： OAI收割
来源：昆明动物研究所
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