Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques
文献类型：期刊论文
| 作者 | Zhang GH1; Han JB1; Chen X1,2; Hu YJ3; Fu LC3; Zheng YT[*]1,4; Zhu L1,2; Luo RH1; Zhang XH1,2 |
| 刊名 | CHINESE MEDICINE
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:X页码:e31 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Aikeqing (AKQ) has been shown in clinical studies to improve quality of life of HIV/AIDS patients, but anti-HIV activity has not been determined. The SHIV-infected macaque is an important animal model for testing antiviral drugs. This study aimed to determine the anti-HIV activity of AKQ in chronically SHIV89.6-infected Chinese rhesus macaques. Methods: Nine Chinese rhesus macaques were inoculated intravenously with SHIV89.6 virus. At 11 weeks post-infection, the animals were arbitrarily divided into three groups: high-dose (AKQ 1.65 g/kg; n = 3), low-dose (AKQ 0.55 g/kg; n = 3), and control (water 1 mL/kg; n = 3). Treatment was administered by the intragastric gavage route once-daily for 8 weeks. Blood (5 mL) was collected biweekly. Viral loads were analyzed by real-time quantitative RT-PCR assays, and T cell counts were monitored by FACS analyses throughout the treatment. Results: AKQ induced a persistent decline (P = 0.02) in plasma viral loads during treatment in the high-dose group compared with their baseline levels, and cessation of the therapy caused viral load rebound to the pretreatment levels. No significant difference (P = 0.06) was found in the plasma viral loads during treatment in the low-dose group. The CD4(+) T cell counts and CD4/CD8 ratios remained at stable high levels during the treatment period. Conclusion: AKQ reduced plasma viral loads in the SHIV89.6-infected Chinese rhesus macaque model. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported in part by Grants from the National Science Founda‑ tion of China (81273251 and 81172876), the National Science and Technology Major Project (2008ZX10005‑005, 2014ZX10005‑002 and 2009ZX09103‑414) and the “Western Light” Projects to Dr. GH Zhang. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10229]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China 3.Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China 4.Kunming Primate Research Center of the Chinese Academy of Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. |
| 推荐引用方式 GB/T 7714 | Zhang GH,Han JB,Chen X,et al. Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques[J]. CHINESE MEDICINE,2016,11(X):e31. |
| APA | Zhang GH.,Han JB.,Chen X.,Hu YJ.,Fu LC.,...&Zhang XH.(2016).Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques.CHINESE MEDICINE,11(X),e31. |
| MLA | Zhang GH,et al."Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques".CHINESE MEDICINE 11.X(2016):e31. |
入库方式： OAI收割
来源：昆明动物研究所
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