The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques
文献类型：期刊论文
| 作者 | Zhang HL1; Liu FL2; Zhuo M1; Liu XH3; Zheng YT[*]2; Ling F[*]1; Jin YB1,2; Deng Q1; Liu BL1 |
| 刊名 | VIROLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 487期号:X页码:222-229 |
| 关键词 | TRIM5 alpha polymorphism HIV-2ROD SIVmac239 Chinese-origin rhesus macaques Vietnamese-origin cynomolgus macaques |
| 通讯作者 | zhengyt@mail.kiz.ac.cn ; fling@scut.edu.cn |
| 英文摘要 | Because of the difficulty of obtaining Indian-origin rhesus macaques, Chinese-origin rhesus macaques (CR) and Vietnamese-origin cynomolgus macaques (CM) are now used frequently in HIV/AIDS research. Nonetheless, the effects of TRIM5 alpha polymorphism on viral replication in both CR and CM are unclear. To address these questions, we recruited 70 unrelated CR and 40 unrelated CM and studied the effect of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs. We found that 3 polymorphisms, located in the B30.2 domain of CR TRIM5 alpha formed a haplotype and affected HIV-2ROD replication. In addition, we found that the variant Y178H, located in the Coiled-coil domain of CM TRIM5 alpha, affected TRIM5 alpha-mediated HIV-2ROD restriction. Finally, two polymorphisms, located in the Coiled-coil domain, altered anti-SIVmac239 activity in CR. We concluded that, CM TRIM5 alpha polymorphism could alter HIV-2ROD infection; however, a different domain of CR TRIM5 alpha was responsible for restricting different virus replication. |
| 收录类别 | SCI |
| 资助信息 | This project was granted by the National Natural Science Foun- dation of China (31271322; 31401088; 81202366; and 81172876) and we thank Dr. Joshua Schraiber from University of Washington for careful editing for our manuscript. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10331]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China 3.Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China |
| 推荐引用方式 GB/T 7714 | Zhang HL,Liu FL,Zhuo M,et al. The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques[J]. VIROLOGY,2016,487(X):222-229. |
| APA | Zhang HL.,Liu FL.,Zhuo M.,Liu XH.,Zheng YT[*].,...&Liu BL.(2016).The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques.VIROLOGY,487(X),222-229. |
| MLA | Zhang HL,et al."The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques".VIROLOGY 487.X(2016):222-229. |
入库方式： OAI收割
来源：昆明动物研究所
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