Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)
文献类型：期刊论文
| 作者 | Feng T1; Su J1; Leng Y2; Liu JK[*]1; Ding ZH1; Zheng YT3; Li Y1 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 59期号:21页码:11690-11695 |
| 关键词 | Zingiber officinale Tongling White Ginger gingerdione dimers gingerol derivatives 11 beta-HSD |
| 通讯作者 | jkliu@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place "Tongling White Ginger" enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M. |
| 收录类别 | SCI |
| 资助信息 | This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113), and MOST (2009ZX09501-029). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10403]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, People’s Republic of China 3.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Feng T,Su J,Leng Y,et al. Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(21):11690-11695. |
| APA | Feng T.,Su J.,Leng Y.,Liu JK[*].,Ding ZH.,...&Li Y.(2011).Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(21),11690-11695. |
| MLA | Feng T,et al."Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.21(2011):11690-11695. |
入库方式： OAI收割
来源：昆明动物研究所
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