Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation
文献类型：期刊论文
| 作者 | Li XS1,2; Zhou XJ2; Yan YM1,4; Zheng YT3; Li Y1; Yang LM3; Cheng YX[*]1; Zhang XJ3; Su J1; Li XJ2 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2011 |
| 卷号 | 74期号:6页码:1521-1525 |
| 通讯作者 | yxcheng@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Fourteen sesquiterpene and norsesquiterpene derivatives, comprising six different carbon skeletons, were isolated from Sanicula lamelligera. Saniculamoid A1 (1a) is an oxidation product of saniculamoid A (1), created by the transition of a formyl group to a carboxylic acid group after a period of storage in air. The known compounds 5-14 were identified in Sanicula plants for the first time. The compounds were evaluated for their anti-HIV-1, cytostatic, and nitric-oxide-production-inhibiting activities using in vitro cellular assays. The results showed that 1,5-naphthalenediol inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 28.1 mu M and was active toward five cancer cell lines with IC50 values in the 31.1-41.6 mu M range. |
| 收录类别 | SCI |
| 资助信息 | This work was supported financially by the following grants: Talent Scholarship of Yunnan Youth (no. 2007PY01-48), a Project from the Traditional Chinese Medicine Scientific Re- search Fund of Hunan Province (no. 2008023), the Open Research Fund of the State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, and the Key Project for Drug Innovation (2008ZX09401-004) from the Ministry of Science and Technol- ogy of China. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10427]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People’s Republic of China 3.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 4.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Li XS,Zhou XJ,Yan YM,et al. Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1521-1525. |
| APA | Li XS.,Zhou XJ.,Yan YM.,Zheng YT.,Li Y.,...&Li XJ.(2011).Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,74(6),1521-1525. |
| MLA | Li XS,et al."Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1521-1525. |
入库方式： OAI收割
来源：昆明动物研究所
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