Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals
文献类型：期刊论文
| 作者 | Zhang L1,3; Luo RH2; Zheng YT2; Liu JK[*]1; Wang F1; Dong ZJ1; Yang LM2 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 71期号:16页码:1879-1883 |
| 关键词 | Trigonostemon thyrsoideum Euphorbiaceae Daphnane diterpenoids Trigonothyrins D-G Anti-HIV-1 |
| 通讯作者 | jkliu@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1,3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13 mu g/mL and a therapeutic index (TI) of 75.1. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported by the National Natural Science Foundation of China (30830113), the National Basic Research Program of China (973 Program, 2009CB522300), and grants (2009ZX09501-029; 2009ZX09501-013). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10443]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 3.Graduate University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Zhang L,Luo RH,Zheng YT,et al. Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals[J]. PHYTOCHEMISTRY,2010,71(16):1879-1883. |
| APA | Zhang L.,Luo RH.,Zheng YT.,Liu JK[*].,Wang F.,...&Yang LM.(2010).Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.PHYTOCHEMISTRY,71(16),1879-1883. |
| MLA | Zhang L,et al."Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals".PHYTOCHEMISTRY 71.16(2010):1879-1883. |
入库方式： OAI收割
来源：昆明动物研究所
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