Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus
文献类型：期刊论文
| 作者 | Zhang JA1,3; Huang N2; Yang LM2; Zheng YT[*]2; Xiao K[*]1; Lu JC3; Li X1,3; Wang YH2 |
| 刊名 | JOURNAL OF FOOD AND DRUG ANALYSIS
 |
| 出版日期 | 2010 |
| 卷号 | 18期号:6页码:398-404 |
| 关键词 | Cyclocarya paliurus phenolics flavonol glucuronides anti-HIV-1 activity Juglandaceae |
| 通讯作者 | zhengyt@mail.kiz.ac.cn ; kaixiaocn@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Eight phenolic compounds including five glucuronides were isolated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja, which is used as a source of tea. Their structures were characterized by spectroscopic methods. The results of biological assay showed that compounds 1 and 5 had good activities against HIV-1 induced cytopathic effects in C8166 lymphocyte at non-cytotoxic concentrations, with EC50 values of 31.74 and 10.76 mu M, and therapeutic index (TI) values of >13.02 and 25.46, respectively. Relationship between molecular structures and their bioactivities was discussed. |
| 收录类别 | SCI |
| 资助信息 | The authors are grateful to the financial support from the National Natural Science Foundation of China (20872179 and 30472141), the Science and Tech- nology Commission of Shanghai Municipality (STCSM) (08DZ1971504), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501- 029, 2008ZX10005-005, KSCX1-YW-10), 973 Program (2009CB522306), and the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10463]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Toxicology & Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China 2.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan provinces, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
| 推荐引用方式 GB/T 7714 | Zhang JA,Huang N,Yang LM,et al. Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus[J]. JOURNAL OF FOOD AND DRUG ANALYSIS,2010,18(6):398-404. |
| APA | Zhang JA.,Huang N.,Yang LM.,Zheng YT[*].,Xiao K[*].,...&Wang YH.(2010).Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus.JOURNAL OF FOOD AND DRUG ANALYSIS,18(6),398-404. |
| MLA | Zhang JA,et al."Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus".JOURNAL OF FOOD AND DRUG ANALYSIS 18.6(2010):398-404. |
入库方式： OAI收割
来源：昆明动物研究所
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