HCV Diversity among Chinese and Burmese IDUs in Dehong, Yunnan, China
文献类型：期刊论文
| 作者 | Wan ZZ1,3; Chen QQ1; Zheng YT[*]2; Zheng CY[*]1; Chen X2,5; Duo L4; Li PL1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:9页码:e0163062 |
| 通讯作者 | zhangcy1999@ips.ac.cn ; zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | HCV transmission is closely associated with drug-trafficking routes in China. Dehong, a prefecture of Yunnan, is the important trade transfer station linking Southeast Asia and China, as well as the drug-trafficking channel linking "Golden triangle" and other regions of China and surrounding countries. In this study, we investigated the HCV genotype diversity among IDUs in Dehong based on 259 HCV positive samples from 118 Chinese and 141 Burmese IDUs. HCV genotypes were determined based on the phylogenies of C/E2 and NS5B genomic sequences. Six HCV subtypes, including 1a, 1b, 3a, 3b, 6n and 6u, were detected. Interestingly, 4 HCV sequences from Burmese IDUs did not cluster with any known HCV subtypes, but formed a well-supported independent clade in the phylogenetic trees of both C/E2 and NS5B, suggesting a potential new HCV subtype circulating in Dehong. Subtype 3b was the predominant subtype, followed by subtypes 6n and 6u. Comparison showed that Dehong had a unique pattern of HCV subtype distribution, obviously different from other regions of China. In particular, HCV subtypes 6u and the potential new HCV subtype had a relatively high prevalence in Dehong, but were rarely detected in other regions of China. There was no significant difference in HCV subtype distribution between Burmese and Chinese IDUs. Few HCV sequences from Burmese and Chinese IDUs clustered together to form transmission clusters. Furthermore, about half of HCV sequences from Burmese IDUs formed small transmission clusters, significantly higher than that from Chinese IDUs (p<0.01). These suggest that the Chinese and Burmese IDUs were relatively isolated from each other in injection drug use behavior and the Burmese IDUs might prefer to inject drugs themselves together. The unique genotype distribution and complex diversity of genotype 6 among IDUs may be associated with the special geographical position of Dehong. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the NSFC(U1302224,81271888,and81271892), Key Scientific and Technological Program of China (2012ZX10001-006)and in part by the Scienceand Technology Support Foundations of Taizhou City (TS201613). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10504]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Pathogen Diagnostic Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, C 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 3.Medical Laboratory of Taizhou Fourth People’s Hospital, Taizhou, Jiangsu 225300, China 4.The Second People’s Hospital of Yunnan Province, Kunming, Yunnan 650031, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China |
| 推荐引用方式 GB/T 7714 | Wan ZZ,Chen QQ,Zheng YT[*],et al. HCV Diversity among Chinese and Burmese IDUs in Dehong, Yunnan, China[J]. PLOS ONE,2016,11(9):e0163062. |
| APA | Wan ZZ.,Chen QQ.,Zheng YT[*].,Zheng CY[*].,Chen X.,...&Li PL.(2016).HCV Diversity among Chinese and Burmese IDUs in Dehong, Yunnan, China.PLOS ONE,11(9),e0163062. |
| MLA | Wan ZZ,et al."HCV Diversity among Chinese and Burmese IDUs in Dehong, Yunnan, China".PLOS ONE 11.9(2016):e0163062. |
入库方式： OAI收割
来源：昆明动物研究所
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