A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity
文献类型：期刊论文
| 作者 | Wang JH1,4; Jing K2,4; Belogortseva N3; Luk'yanov P3; Zheng YT[*]1; Wei L2; Molchanova V3; Chikalovets I3 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 142期号:1-2页码:111-117 |
| 关键词 | HIV-1 antiviral activity entry inhibitor CVL beta-galactose-specific lectin |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A 30 kDa beta-galactose-specific lectin named CVL was isolated from the polychaete marine worm Chaetopterus variopedatus (Annelida) and its anti-HIV-1 activity in vitro was determined. Results showed that CVL inhibited cytopathic effect induced by HIV-1 and the production of viral p24 antigen. The EC50 values were 0.0043 and 0.057 mu M, respectively. Time-of-addition analysis of anti-HIV-1 activity indicated its action was at the early stage of virus replication. CVL could blocked the cell-to-cell fusion process of HIV infected and uninfected cells with an EC50 of 0.073 mu M. The inhibition of HIV-1 entry into host cells was demonstrated by using fluorescence-based real-time quantify PCR. At CVL concentration of 0.33 mu M and 0.07 mu M, 86% and 21% virus attachment were blocked, respectively. The anti-HIV-1 action of CVL might relate to blockade of HIV-1 entry into cells. (c) 2005 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by grants from the Natural Science Foundation of China (30471605) and Yunnan Province (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216; KSCX1-SW-11), Key Scientific and Tech- nological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y.T. Zheng. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10587]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China 3.Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia 4.The Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Wang JH,Jing K,Belogortseva N,et al. A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2006,142(1-2):111-117. |
| APA | Wang JH.,Jing K.,Belogortseva N.,Luk'yanov P.,Zheng YT[*].,...&Chikalovets I.(2006).A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,142(1-2),111-117. |
| MLA | Wang JH,et al."A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 142.1-2(2006):111-117. |
入库方式： OAI收割
来源：昆明动物研究所
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