Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication
文献类型：期刊论文
| 作者 | Zhu JW1,2; Liu FL1; Mu D1; Deng DY3; Zheng YT[*]1,2 |
| 刊名 | Microbes and Infection
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:In Press |
| 关键词 | APOBEC3G Heroin use TRIM22 TRIM5α Type I interferon |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | Heroin use is associated with increased incidence of infectious diseases such as HIV-1 infection, as a result of immunosuppression to a certain extent. Host restriction factors are recently identified cellular proteins with potent antiviral activities. Whether heroin use impacts on the in vivo expression of restriction factors that result in facilitating HIV-1 replication is poorly understood. Here we recruited 432 intravenous drug users (IDUs) and 164 non-IDUs at high-risk behaviors. Based on serological tests, significantly higher prevalence of HIV-1 infection was observed among IDUs compared with non-IDUs. We included those IDUs and non-IDUs without HIV-1 infection, and found IDUs had significantly lower levels of TRIM5α, TRIM22, APOBEC3G, and IFN-α, -β expression than did non-IDUs. We also directly examined plasma viral load in HIV-1 mono-infected IDUs and non-IDUs and found HIV-1 mono-infected IDUs had significantly higher plasma viral load than did non-IDUs. Moreover, intrinsically positive correlation between type I interferon and TRIM5α or TRIM22 was observed, however, which was dysregulated following heroin use. Collectively, heroin use benefits HIV-1 replication that may be partly due to suppression of host restriction factors and type I interferon expression. |
| 资助信息 | This study was supported in part by grants from the Na- tional Natural Science Foundation of China (81202366, 81271892, U1302224, U0832601), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW- R-12, KJZD-EW-L10-02), and Yunnan Applicative and Basic Research Program (2013FB073). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10835]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.Department of Clinical Laboratory, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China |
| 推荐引用方式 GB/T 7714 | Zhu JW,Liu FL,Mu D,et al. Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication[J]. Microbes and Infection,2017,**(**):In Press. |
| APA | Zhu JW,Liu FL,Mu D,Deng DY,&Zheng YT[*].(2017).Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication.Microbes and Infection,**(**),In Press. |
| MLA | Zhu JW,et al."Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication".Microbes and Infection **.**(2017):In Press. |
入库方式： OAI收割
来源：昆明动物研究所
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