The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies
文献类型：期刊论文
| 作者 | Achilli A1,2; Perego UA1,3; Bravi CM4; Coble MD5; Kong QP6,7; Woodward SR3; Salas A8; Torroni A[*]1; Bandelt HJ9 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2008 |
| 卷号 | 3期号:3页码:e1764 |
| 关键词 | PUBLIC LIBRARY SCIENCE 185 BERRY ST STE 1300 SAN FRANCISCO CA 94107 USA |
| 通讯作者 | torroni@ipvgen.unipv.it |
| 合作状况 | 其它 |
| 英文摘要 | Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub-haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived clades are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrasts with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds. |
| 收录类别 | SCI |
| 资助信息 | This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. |
| 语种 | 英语 |
| 公开日期 | 2010-11-02 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6351]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Dipartimento di Genetica e Microbiologia, Universita ` di Pavia, Pavia, Italy 2.Dipartimento di Biologia Cellulare e Ambientale, Universita ` degli Studi di Perugia, Perugia, Italy 3.Sorenson Molecular Genealogy Foundation, Salt Lake City, Utah, United States of America 4.Laboratorio de Gene ´tica Molecular Poblacional, Instituto Multidisciplinario de Biologı ´a Celular (IMBICE), La Plata, Argentina 5.Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, Rockville, Maryland, United States of America 6.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 7.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 8.Unidade de Xene ´tica, Instituto de Medicina Legal, Facultad de Medicina, Universidad de Santiago de Compostela, Grupo de Medicina Xeno ´mica, Hospital Clı ´nico Universitario, Santiago de Compostela, Galicia, Spain 9.Department of Mathematics, University of Hamburg, Hamburg, Germany |
| 推荐引用方式 GB/T 7714 | Achilli A,Perego UA,Bravi CM,et al. The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies[J]. PLOS ONE,2008,3(3):e1764. |
| APA | Achilli A.,Perego UA.,Bravi CM.,Coble MD.,Kong QP.,...&Bandelt HJ.(2008).The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies.PLOS ONE,3(3),e1764. |
| MLA | Achilli A,et al."The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies".PLOS ONE 3.3(2008):e1764. |
入库方式： OAI收割
来源：昆明动物研究所
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