The role of ROS toxicity in spontaneous aneuploidy in cultured cells
文献类型：期刊论文
| 作者 | Wang CY[*]1; Liu LN2; Zhao ZB3 |
| 刊名 | TISSUE & CELL
 |
| 出版日期 | 2013 |
| 卷号 | 45期号:1页码:47-53 |
| 关键词 | Aneuploidy Chromosome Reactive oxygen species Cell culture |
| 通讯作者 | chengyewang@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | It is well known that the karyotype of animal cells cultured in vitro tends to become aneuploid as the culture ages. Aneuploidy can cause genetic instability, alter the biological properties of cells, and affect their application in genetic studies and cell engineering. Understanding the causes and mechanisms of aneuploidy is primary to control its occurrence in cultured cells, and is also helpful to understand the mechanisms of tumorigenesis because aneuploidy is a hallmark of tumor cells. This review underscores the potential role of reactive oxygen species (ROS) toxicity in spontaneous aneuploidy of cultured cells. The underlying mechanisms and possible sources of ROS are also discussed. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a grant from the National Natural Science Foundation of China (No. 31101668). |
| 语种 | 英语 |
| WOS记录号 | WOS:000321560800006 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7666]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration, Research Institute of Resource Insects, Chinese Academy of Forestry, Kunming 650224, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Ecology, Environmental Management College of China, Qinhuangdao 066004, China |
| 推荐引用方式 GB/T 7714 | Wang CY[*],Liu LN,Zhao ZB. The role of ROS toxicity in spontaneous aneuploidy in cultured cells[J]. TISSUE & CELL,2013,45(1):47-53. |
| APA | Wang CY[*],Liu LN,&Zhao ZB.(2013).The role of ROS toxicity in spontaneous aneuploidy in cultured cells.TISSUE & CELL,45(1),47-53. |
| MLA | Wang CY[*],et al."The role of ROS toxicity in spontaneous aneuploidy in cultured cells".TISSUE & CELL 45.1(2013):47-53. |
入库方式： OAI收割
来源：昆明动物研究所
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