The calcium-sensing receptor R990G polymorphismis associated with increased risk of hypertriglyceridemia in obese Chinese
文献类型：期刊论文
| 作者 | He YH1,4; Kong WL2; Wang G1; Zhao Y1; Bi MX1; Na LX1; Wang MQ1; Perry B3; Li Y[*]1 |
| 刊名 | GENE
 |
| 出版日期 | 2014 |
| 卷号 | 533期号:1页码:67-71 |
| 关键词 | Calcium-sensing receptor Polymorphism Hypertriglyceridemia Obesity |
| 通讯作者 | liying_helen@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Background: We have demonstrated that the calcium-sensing receptor (CaSR) is involved in lipid metabolism; however, whether CaSR polymorphisms affect lipid metabolism in obesity is still unclear. The present study aimed to determine the effects of CaSR polymorphisms on HTG risk in obese Chinese. Methods: A total of 972 subjects with HTG and 1197 with normal triglyceride (NTG) were stratified by body mass index (BMI) into normal weight, overweight or obesity subgroups. After 12-h fasting, CaSR polymorphisms in exon 7 were determined in the blood. Serum lipids and glucose, as well as height, body weight and waist circumference were measured. The anthropometric and metabolic characteristics of the NTG subjects were re-evaluated 3 years later. Results: There were no genotypic or allelic distribution differences for the A986S or Q1011E polymorphisms between the NTG and HTG groups. However, the GIG genotypic and G allelic distributions of the CaSR R990G polymorphism in the HTG group were higher than the NTG group (p < 0.001). After stratification, in obese subjects, the homozygous (GIG) distribution of the CaSR R990G polymorphism in the HTG group was significantly higher than in the NTG group (p = 0.001), and showed an increased risk of HTG at baseline [OR = 2.55,95% CI = 1.65-3.92, p<0.006]. Interaction of the CaSR R990G polymorphism with BMI was associated with increased risk of HTG (beta=0.927, p<0.001). Re-evaluation of the NTG subjects revealed significantly increased serum triglyceride levels in obese homozygous versus wildtype carriers (p<0.05). Conclusions: These results suggest that the CaSR R990G polymorphism is associated with increased risk of HTG, especially in obese Chinese, and may be a potential genetic predictor of diseases related to HTG |
| 收录类别 | SCI |
| 资助信息 | This work was funded by the Program for New Century Excellent Talents (NCET-10-0148), the National Natural Science Fund of China key project (81130049) and the National 12th Five-Year Scientific and Technical Program of China (2012BAI02B02). |
| 语种 | 英语 |
| 公开日期 | 2014-06-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7865]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.National Key Discipline of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, China 2.The First Affiliated Hospital, Harbin Medical University, China 3.Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, PE, Canada 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | He YH,Kong WL,Wang G,et al. The calcium-sensing receptor R990G polymorphismis associated with increased risk of hypertriglyceridemia in obese Chinese[J]. GENE,2014,533(1):67-71. |
| APA | He YH.,Kong WL.,Wang G.,Zhao Y.,Bi MX.,...&Li Y[*].(2014).The calcium-sensing receptor R990G polymorphismis associated with increased risk of hypertriglyceridemia in obese Chinese.GENE,533(1),67-71. |
| MLA | He YH,et al."The calcium-sensing receptor R990G polymorphismis associated with increased risk of hypertriglyceridemia in obese Chinese".GENE 533.1(2014):67-71. |
入库方式： OAI收割
来源：昆明动物研究所
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