Mitochondrial DNA content contributes to healthy aging in Chinese:a study from nonagenarians and centenarians
文献类型：期刊论文
| 作者 | He YH1,3; Lu X1,3; Wu H1,3; Cai WW[*]2; Yang LQ1,3; Xu LY4; Sun HP5; Kong QP[*]1,3 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:7页码:1779.e1-4 |
| 关键词 | Age-related diseases Aging Copy number Longevity Mitochondrial DNA |
| 通讯作者 | caiww591020@163.com ; kongqp@mail.kiz.ac.cn |
| 英文摘要 | Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function. A decline in the mtDNA content and subsequent dysfunction cause various senile diseases, with decreasing mtDNA content observed in the elderly individuals with age-related diseases. In contrast, the oldest old individuals, for example, centenarians, have a delayed or reduced prevalence of these diseases, suggesting centenarians may have a different pattern of the mtDNA content, enabling them to keep normal mitochondrial functions to help delay or escape senile diseases. To test this hypothesis, a total of 961 subjects, consisting of 424 longevity subjects and 537 younger control subjects from Hainan and Sichuan provinces of China, were recruited for this study. The mtDNA content was found to be inversely associated with age among the age of group 40-70 years. Surprisingly, no reduction of mtDNA content was observed in nonagenarians and centenarians; instead, these oldest old showed a significant increase than the elderly people aged between 50 and 70 years. The results suggest the higher mtDNA content may convey a beneficial effect to the longevity of people through assuring sufficient energy supply. |
| 收录类别 | SCI |
| 资助信息 | This work was supported bygrants from National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024), the Chinese Academy of Sciences, Natural Science Foundation of China (31100909, 31123005, and 31322029), and the Department of Science and Technology of Hainan Province (013GH XM0025). |
| 语种 | 英语 |
| 公开日期 | 2014-06-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7867]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China 2.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China 3.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 4.Dujiangyan Longevity Research Centre, Dujiangyan, China 5.Department of Social Medicine, School of Public Health, Soochow University, Suzhou, China |
| 推荐引用方式 GB/T 7714 | He YH,Lu X,Wu H,et al. Mitochondrial DNA content contributes to healthy aging in Chinese:a study from nonagenarians and centenarians[J]. NEUROBIOLOGY OF AGING,2014,35(7):1779.e1-4. |
| APA | He YH.,Lu X.,Wu H.,Cai WW[*].,Yang LQ.,...&Kong QP[*].(2014).Mitochondrial DNA content contributes to healthy aging in Chinese:a study from nonagenarians and centenarians.NEUROBIOLOGY OF AGING,35(7),1779.e1-4. |
| MLA | He YH,et al."Mitochondrial DNA content contributes to healthy aging in Chinese:a study from nonagenarians and centenarians".NEUROBIOLOGY OF AGING 35.7(2014):1779.e1-4. |
入库方式： OAI收割
来源：昆明动物研究所
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