中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population

文献类型:期刊论文

作者Liu LN1; Wang CY2; Lu X1; Xiao FH1; Wang HW1; Yang LQ1; Xu LY3; Kong QP[*]1
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2014
卷号57期号:10页码:1024-1027
通讯作者kongqp@mail.kiz.ac.cn
合作状况其它
英文摘要MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals (age[Symbol: see text]90, mean 94.45±3.45 years) and 332 normal controls (age 22-53, mean 35.0±12.0 years) from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Han Chinese population studied here.
收录类别SCI
资助信息This work was supported by the National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024), the National Natural Science Foundation of China (31100909) and the Chinese Academy of Sciences.
语种英语
WOS记录号WOS:000343348300010
公开日期2014-10-29
源URL[http://159.226.149.42:8088/handle/152453/8157]  
专题昆明动物研究所_分子人类学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2.Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration, Research Institute of Resource Insects, Chinese Academy of Forestry, Kunming 650224, China
3.Dujiangyan Longevity Research Center, Dujiangyan 611830, China
推荐引用方式
GB/T 7714
Liu LN,Wang CY,Lu X,et al. The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(10):1024-1027.
APA Liu LN.,Wang CY.,Lu X.,Xiao FH.,Wang HW.,...&Kong QP[*].(2014).The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population.SCIENCE CHINA-LIFE SCIENCES,57(10),1024-1027.
MLA Liu LN,et al."The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population".SCIENCE CHINA-LIFE SCIENCES 57.10(2014):1024-1027.

入库方式: OAI收割

来源:昆明动物研究所

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