The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population
文献类型：期刊论文
| 作者 | Liu LN1; Wang CY2; Lu X1; Xiao FH1; Wang HW1; Yang LQ1; Xu LY3; Kong QP[*]1 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2014 |
| 卷号 | 57期号:10页码:1024-1027 |
| 通讯作者 | kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals (age[Symbol: see text]90, mean 94.45±3.45 years) and 332 normal controls (age 22-53, mean 35.0±12.0 years) from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Han Chinese population studied here. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024), the National Natural Science Foundation of China (31100909) and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000343348300010 |
| 公开日期 | 2014-10-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8157]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration, Research Institute of Resource Insects, Chinese Academy of Forestry, Kunming 650224, China 3.Dujiangyan Longevity Research Center, Dujiangyan 611830, China |
| 推荐引用方式 GB/T 7714 | Liu LN,Wang CY,Lu X,et al. The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(10):1024-1027. |
| APA | Liu LN.,Wang CY.,Lu X.,Xiao FH.,Wang HW.,...&Kong QP[*].(2014).The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population.SCIENCE CHINA-LIFE SCIENCES,57(10),1024-1027. |
| MLA | Liu LN,et al."The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population".SCIENCE CHINA-LIFE SCIENCES 57.10(2014):1024-1027. |
入库方式： OAI收割
来源：昆明动物研究所
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