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Evaluating the Susceptibility of Mitochondrial DNA Germline Mutations in Chinese Cancer Patients

文献类型：期刊论文

作者Liu J1,2,5; Xu LY4; Li RL6; Li EM[*]3; Kong QP[*]1,2
刊名CURRENT MOLECULAR MEDICINE
出版日期2014
卷号14期号:10页码:1265-1272
关键词Cancer germline mutation mitochondrial DNA mutation pattern
通讯作者kongqp@mail.kiz.ac.cn an ; nmli@stu.edu.cn
合作状况其它
英文摘要It has been suggested that impairment of mitochondrial oxidative phosphorylation (OXPHOS) is a common character in cancer cells, urging attention to variation on mitochondrial DNA (mtDNA) that encodes 13 units of the OXPHOS. However, most of mtDNA somatic mutations in cancer were suggested to result from the relaxed functional constrains and thus the byproducts of tumorigenesis. MtDNA germline mutations present not only in the cancer tissue but also in the normal tissue. However, it remains unclear whether the cancerous mtDNA germline mutations suffered similar selective constraints as the somatic mutations did. To address this question, we collected 153 whole mitochondrial genomes (including 20 newly obtained genomes in this study) from the normal tissues of cancer patients and compared with a number of 561 whole mtDNA sequences from the general population in China. Different from the observations on cancerous mtDNA somatic mutations, our results revealed that the germline mutations showed no significant difference between the cancer patients and the general population in either the sub-haplogroup composition, mutation pattern or the potential pathogenicity of the private mutations. It then seems that regulation on cellular OXPHOS level, triggered by mtDNA variation to some extent, exerts little influence on the susceptibility of cancer, which echoes the opinion that aerobic glycolysis, not mitochondrial respiration, plays the key role in generating energy in cancer cells, thus suggesting the role of most mtDNA mutations in cancer likely being overestimated.
收录类别SCI
资助信息This work was supported by grants from the National Natural Science Foundation of China (81272309, 31123005), the Chinese Academy of Sciences (KSCXZ-EW-J-23), the Natural Science Foundation of China-Guangdong Joint Fund (U1301227), the National Basic Research Program (2012CB526608) and the National High Technology Research and Development Program of China (2012AA02A209).
语种英语
WOS记录号WOS:000346161900004
公开日期2015-01-12
源URL[http://159.226.149.42:8088/handle/152453/8219]  
专题昆明动物研究所_分子人类学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Kunming 650223, China
2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China
3.Department of Biochemistry and Molecular Biology, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, China
4.Institute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, China
5.University of Chinese Academy of Sciences, Beijing 100049, China
6.School of Life Sciences Yunnan University, Kunming 650031, China
推荐引用方式
GB/T 7714		 Liu J,Xu LY,Li RL,et al. Evaluating the Susceptibility of Mitochondrial DNA Germline Mutations in Chinese Cancer Patients[J]. CURRENT MOLECULAR MEDICINE,2014,14(10):1265-1272.
APA Liu J,Xu LY,Li RL,Li EM[*],&Kong QP[*].(2014).Evaluating the Susceptibility of Mitochondrial DNA Germline Mutations in Chinese Cancer Patients.CURRENT MOLECULAR MEDICINE,14(10),1265-1272.
MLA Liu J,et al."Evaluating the Susceptibility of Mitochondrial DNA Germline Mutations in Chinese Cancer Patients".CURRENT MOLECULAR MEDICINE 14.10(2014):1265-1272.

入库方式： OAI收割

来源：昆明动物研究所

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