A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes
文献类型：期刊论文
| 作者 | Xiao FH1,2,3; He YH1,2; Li QG1,2; Wu H1,2; Luo LH[*]4; Kong QP[*]1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:3页码:e0120388 |
| 通讯作者 | luolh@genomics.cn ; kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | It is recognized that genetic factors contribute to human longevity. Besides the hypothesis of existence of longevity genes, another suggests that a lower frequency of risk alleles decreases the incidence of age-related diseases in the long-lived people. However, the latter finds no support from recent genetic studies. Considering the crucial role of epigenetic modification in gene regulation, we then hypothesize that suppressing disease-related genes in longevity individuals is likely achieved by epigenetic modification, e.g. DNA methylation. To test this hypothesis, we investigated the genome-wide methylation profile in 4 Chinese female centenarians and 4 middle-aged controls using methyl-DNA immunoprecipitation sequencing. 626 differentially methylated regions (DMRs) were observed between both groups. Interestingly, genes with these DMRs were enriched in age-related diseases, including type-2 diabetes, cardiovascular disease, stroke and Alzheimer's disease. This pattern remains rather stable after including methylomes of two white individuals. Further analyses suggest that the observed DMRs likely have functional roles in regulating disease-associated gene expressions, with some genes [e.g. caspase 3 (CASP3)] being down-regulated whereas the others [i.e. interleukin 1 receptor, type 2 (IL1R2)] up-regulated. Therefore, our study suggests that suppressing the disease-related genes via epigenetic modification is an important contributor to human longevity. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024, 2013FB069), the Chinese Academy of Sciences, Natural Science Foundation of China (31123005, 31322029). |
| 语种 | 英语 |
| WOS记录号 | WOS:000352083900021 |
| 公开日期 | 2015-05-11 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8328]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China 3.University of Chinese Academy of Sciences, Beijing, China 4.Beijing Genome Institute at Shenzhen, Shenzhen, China |
| 推荐引用方式 GB/T 7714 | Xiao FH,He YH,Li QG,et al. A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes[J]. PLOS ONE,2015,10(3):e0120388. |
| APA | Xiao FH,He YH,Li QG,Wu H,Luo LH[*],&Kong QP[*].(2015).A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes.PLOS ONE,10(3),e0120388. |
| MLA | Xiao FH,et al."A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes".PLOS ONE 10.3(2015):e0120388. |
入库方式： OAI收割
来源：昆明动物研究所
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