The reduction of vascular disease risk mutations contributes to longevity in the Chinese population
文献类型：期刊论文
| 作者 | He YH1,2; Lu X1,2; Bi MX3; Yang LQ1,2; Xu LY4; Kong QP[*]1,2 |
| 刊名 | META GENE
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:X页码:761-768 |
| 关键词 | genome-wide association AD Alzheimer Disease CHB, Chinese Han Beijing CVD, cardiovascular disease Cardiovascular disease GWAS |
| 通讯作者 | kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | AIM: Genetic factors play important roles in determining human lifespan. Although some "longevity genes" have been identified to be implicated in human longevity, many disease-associated variants were also observed in the long-lived individuals. The oldest old and their offspring usually have a lower prevalence of age-related diseases, which is likely attributed to a reduction or an absence of disease risk variants. METHODS AND RESULTS: To test this hypothesis, 23 disease risk single nucleotide polymorphisms (SNPs), identified by previous genome-wide association studies (GWASs), were selected and genotyped in 1074 samples consisting of 574 longevity subjects (over 90years old) and 500 younger controls. Our results revealed that 5 SNPs (rs2144300, rs1864163, rs2200733, rs1967017, and rs7193343) displayed significantly lower allelic frequencies and odds ratios (ORs) in the longevity group than that in the control group. The frequencies of homozygous mutation genotypes and corresponding ORs of the rs1864163, rs2200733, rs127430, rs1967017, and rs12413409 were lower in the longevity subjects. Interestingly, most of the abovementioned SNPs convey susceptibility to cardiovascular disease (CVD), which is the leading cause of deaths in old adults but shows a much lower incidence in the longevity individuals and their offspring. CONCLUSION: Taking into account the observation that the longevity subjects and their offspring have lower rate of cardiovascular mortality, it is then most plausible that the lack of disease risk variants, especially the CVD, is a genetic contributor to longevity in the Chinese population. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024, 2013FB069), the West Light Foundation of The Chinese Academy of Sciences and the National Natural Science Foundation of China (31123005, 31322029). |
| 语种 | 英语 |
| 公开日期 | 2015-06-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8364]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China 3.Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150081, China 4.Dujiangyan Longevity Research Centre, Dujiangyan 611830, China |
| 推荐引用方式 GB/T 7714 | He YH,Lu X,Bi MX,et al. The reduction of vascular disease risk mutations contributes to longevity in the Chinese population[J]. META GENE,2014,2(X):761-768. |
| APA | He YH,Lu X,Bi MX,Yang LQ,Xu LY,&Kong QP[*].(2014).The reduction of vascular disease risk mutations contributes to longevity in the Chinese population.META GENE,2(X),761-768. |
| MLA | He YH,et al."The reduction of vascular disease risk mutations contributes to longevity in the Chinese population".META GENE 2.X(2014):761-768. |
入库方式： OAI收割
来源：昆明动物研究所
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